最佳Genomics播客 (2024)

1
Ancient Artifacts Inside Your DNA 10:37

28d ago10:37

10:37

In this episode, Dr. Dan Handley takes us into the fascinating world of proteins—those powerhouse molecules that do the heavy lifting in our bodies. While the human genome contains about 20,000 protein-coding genes, these genes produce over 100,000 different proteins, thanks to nature's incredible complexities. Dr. Handley breaks down the science b…

1
Illumina Scales Variant Calling and Genome Interpretation to Improve Gaps in Genetic Testing 31:19

8M ago31:19

31:19

1
How Do You Train Genomics AI? On Natural Selection Itself, Says VP of Illumina's AI Lab, Kyle Farh 28:20

8M ago28:20

28:20

1
Two Industry Leaders on the Growing Complexity of Genomic Cancer Data 32:51

8M ago32:51

32:51

1
Does finding a rare mutation accomplish anything? 4:34

8M ago4:34

4:34

1
ctDNA-guided treatment in colorectal cancer 4:14

8M ago4:14

4:14

1
Clinical utility of ctDNA testing in lung cancer 4:24

8M ago4:24

4:24

1
Liquid biopsy NGS in cancer care 5:56

1+ y ago5:56

5:56

1
Genetic counselling in an era of prenatal screening, tools to support patient informed consent 11:42

1+ y ago11:42

11:42

1
Testing for NTRK Fusions 6:17

2y ago6:17

6:17

1
Homologous Recombination Deficiency (HRD) Testing in Ovarian Cancer 5:26

2y ago5:26

5:26

1
Transposons and epigenetic priming of enhancers within early human embryo development with Dr Christopher Todd 1:26:40

2+ y ago1:26:40

1:26:40

In today's episode I spoke again to Dr Christopher Todd from the Babraham institute. Chris is a postdoctoral researcher in Wolf Reiks lab who talked to me about transposable elements and epigenetic priming of enhancers with human embryonic development. Chris gave a great talk at GREECS 2022 where he discussed his research and I absolutely loved his…

1
Neuroscience meets epigenetics - Doctor Ben Rein 1:27:07

3y ago1:27:07

1:27:07

TGL made it to 2022! On todays episode, I spoke to Dr Benjamin Rein, a neuroscientist all the way from Stanford. We speak all about Bens experience of science communication on social media, Ben uses Tik Tok & instagram to make awesome short videos on scientific papers and topics and has gained a following of +600,000 on tik tok! He also talks all a…

1
Alternative Splicing - Nature's Mad Scientist 6:02

3y ago6:02

6:02

In the last episode on the central dogma of molecular biology, DNA Dan discussed the information flow of DNA, to RNA, to amino acid sequences that make up proteins. In this episode, Dr. Handley discusses proteins - the work horses of the body, and the extensive roles they play in our bodies. By last known count, there are around 20,000 protein codi…

1
The Central Dogma of Molecular Biology 7:54

3y ago7:54

7:54

In episodes 2, 3 and 4 of this podcast, we've learned that DNA is determined to be the molecule of inheritance, as well as how its structure is determined. What DNA Dan hasn't yet discussed is what DNA actually does. Or, if DNA is the so called "code of life," how is its code being read? And how is that information put into action? That brings us t…

1
Spatial transcriptomics with Dr Patrick CN Martin 1:17:27

3y ago1:17:27

1:17:27

In today's episode I spoke again to Dr Patrick CN Martin from the Biotech research and innovation centre at the University of Copenhagen, about spatial transcriptomics. Patrick is a post doctoral researcher who has been working on ST and more specifically, this pre print which we also took a deep dive into, on todays episode! Patricks new tool, nam…

1
The Other Human Genome 6:13

3y ago6:13

6:13

If you think back to your early years of biology class, you may remember learning about tiny cellular energy factories, called mitochondira. Mitochondria are microscopic powerhouses hiding within most cells and they play a huge role in our health. Damaged mitochondria can lead to a host of health issues. But healthy mitochondria can result in optim…

1
Epigenetics & fertility with Alka Gupta 1:11:46

3y ago1:11:46

1:11:46

This week I spoke to Alka Gupta. Alka has just finished up her PhD and begun her postdoctoral position at UCSC in the Sharma Lab where she is now working on epigenetic inheritance. Today we spoke about her PhD research in which she was looking at the role of microRNAs in male infertility. We learnt about Sertoli cells, spermatogenesis and shrinking…

1
Biomarkers in genomics with Dr Paul Okunieff 54:59

3y ago54:59

54:59

Today I speak to Dr Paul Okunieff , founder and consultant of Diacarta. DiaCarta is a leading translational genomics and personalized diagnostics company based in California. DiaCarta provides highly sensitive and advanced technologies aiming to change the landscape of precision medicine and molecular diagnostics by impacting healthcare treatment p…

1
Shotgun Sequencing and the Human Genome Project 6:35

3y ago6:35

6:35

Over the 1960s through 1980s, more was learned about the structure of chromosomes and the functions of some genes. However, we did not have a comprehensive map of the entire human genome. Learn how molecular biology techniques become more sophisticated, and scientists could start determining the nucleotide sequence of small portions of chromosomes.…

1
How to Get Six Feet of DNA into a Six Micron Suitcase 4:25

3y ago4:25

4:25

In each nucleus of a human cell, the total length of DNA contained in it is about 6 feet long. Now, the size of a nucleus in a human cell is only 6 microns in width. A micron, otherwise called a micrometer, is 1 one-millionth of a meter. To put this in perspective, the average human hair is about 100 micrometers in diameter, and a grain of salt is …

1
The dark matter of the genome with Sudarshan Pinglay 1:09:23

3y ago1:09:23

1:09:23

On todays episode, I speak to Sudarshan Pinglay, a PhD student from NYU medical center. Sudarshan is involved in the dark matter project- we talk about the dark matter of the genome, where introns, repetitive and regulatory elements reside. Sudarshan works specifically on the HOXA locus. The Hox family of genes pattern the head to tail axis in the …

1
The immune system: B cells and Epigenetics with Dr Hamish King 1:14:31

3y ago1:14:31

1:14:31

In todays episode, I speak to Dr Hamish King, a Sir Henry Wellcome Fellow affiliated with the Blizard Institute at Queen Mary University of London. Hamish is interested in how errors in gene regulation lead to changes in the behaviour and function of B cells, an important cell type in our immune system that makes antibodies to fight and remember in…

1
Epigenetic biomarkers of exposure to tobacco smoke : A biosocial approach with Alexandria Andrayas 1:02:21

3y ago1:02:21

1:02:21

Welcome to Episode 29 of The Genomics Lab! On today's episode we talk to Alexandria Andrayas who is a PhD candidate in the Soc-B Centre for doctoral training which is a new and unique programme in biosocial research. The programme is funded by the Economic and Social Research Council and the Biotechnology & Biological Sciences Research Council. It …

1
What We Now Know About the Structure of DNA 5:40

3y ago5:40

5:40

Today we understand much more detail about the structure of DNA. It turns out that Watson, Crick, Wilkins, Franklin, and the many others involved gave essentially the correct answer about the DNA molecule and how it is structured. ------------------------------------------ Join DNA Dan each month as he dives deep into the world of genetics, genomic…

1
Dissecting the binding mechanisms of Transcription Factors to DNA with Dr Patrick CN Martin 1:10:52

3+ y ago1:10:52

1:10:52

Welcome to Episode 28 of The Genomics Lab! On today's episode we talk to Dr.Patrick CN Martin who is a postdoctoral researcher at the University of Copenhagen. He completed his PhD in Dr Radu Zabets lab in 2020 where he investigated the binding mechanisms of transcription factors to DNA. His research involved development of an R package, ChIPAnalys…

1
The Rosalind Franklin Controversy 5:50

3+ y ago5:50

5:50

Rosalind Franklin played a pivotal role in the discovery of the structure of DNA. Among scholarly circles, Franklin remains an enigmatic figure and the subject of much controversy. What is not under debate is that she made enormous contributions to science, and she was taken from us much too soon. ------------------------------------------ Join DNA…

1
Remote control of gene expression: enhancers and the 4D genome with Professor Wendy Bickmore 1:16:42

3+ y ago1:16:42

1:16:42

This week we are honoured to host Professor Wendy Bickmore, the Director of the MRC Human Genetics unit at the University of Edinburgh. Wendys research laboratory focuses on trying to better understand the 3D organisation of the genome, and how this controls how the genome functions during normal development. They are further interested in how this…

1
Discovering the Structure of DNA 9:46

3+ y ago9:46

9:46

Now the race was on to figure out the structure of DNA. It’s a rather complex story involving many different scientists, primarily in the U.S. and England. ------------------------------------------ Join DNA Dan each month as he dives deep into the world of genetics, genomics, DNA, and the future of precision genomic medicine. Dan discusses health …

1
The Discovery of DNA - Part 2 7:07

3+ y ago7:07

7:07

In this episode, part 2 of the discovery of DNA, we come to understand how DNA was first isolated and demonstrated to be the molecule responsible for heritable traits. In the early to mid-19th century, biologists assumed that heritable traits were transmitted by proteins in cells. ------------------------------------------ Join DNA Dan each month a…

1
The Discovery of DNA - Part 1 6:53

3+ y ago6:53

6:53

Since prehistoric times, people have noticed how children tend to resemble their parents and grandparents. People also recognized that some human diseases tended to run in families as well. Learn why this happens and how it was discovered. What is the substance in cells that carries the heritable trait information? Further, what is the structure of…

1
Rattlesnakes and Population Genomics with Kat Ivey 1:11:04

3+ y ago1:11:04

1:11:04

Welcome back! Today we are talking to Kathleen Ivey, a PhD student from the University of Texas at Arlington in the Castoe Lab. Kat talks to us all about her journey to her PhD, with a background in vet tech & herpetology. Kat now focuses on population genomics, with a particular interest in Rattlesnakes. She tells us all about being out in the fie…

1
Meet DNA Dan 7:09

3+ y ago7:09

7:09

Dr. Handley serves as Director of the Master of Science in Human Genetics and Genomics degree program at the Southern California University of Health Sciences in Whittier, CA. He is excited to bring you this podcast on genetics, genomics, and the future of genomic medicine! Join DNA Dan each month as he dives deep into the world of genetics, genomi…

1
Making connections between epigenetics and evolution with Dr Peter Sarkies 1:21:20

3+ y ago1:21:20

1:21:20

Welcome back for another episode! This week we chat to Dr Peter Sarkies from Imperial College London / MRC LMS! Peter is a senior lecturer running his own laboratory which aims to make connections between epigenetic gene regulation and evolution. Peter talks to us all about his research involving investigation of a wide range of epigenetic pathways…

1
Epigenetic regulation in neurodegenerative diseases with Dr Sarah Marzi 1:06:30

3+ y ago1:06:30

1:06:30

On todays episode, we talk to Dr Sarah Marzi from Imperial College London all about her work into the epigenetic regulation in neurodegenerative diseases like Alzheimers and Parkinsons. Sarah tells us about her journey into this field and describes what exactly neurodegenerative diseases are?! She also talks to us about her contributions to the fie…

1
DNA nanotechnology with Dr Andrew J Lee 59:51

3+ y ago59:51

59:51

This week we took a slight detour away from our normal topic of conversation (Genomics) and immersed ourselves into the world of DNA nanotechnology with Dr Andrew J Lee, the centre manager of the Bragg Centre for materials research. Andy is a weaver of DNA and nanoscale filmaker in the Bioelectronics group. He develops nanostructures that are self …

1
Non-CG Methylation and its Role in Development with Dr Ozren Bogdanovic 59:35

3+ y ago59:35

59:35

Our second guest from the Garvan Institute of Medical Research in Sydney, is DrOzren Bogdanovic. We are so privileged to talk today to Ozren about his work in developmental epigenetics which covers how DNA methylation participates in diverse developmental processes, and how deposition and removal of the methylation mark impacts upon embryonic and g…

1
The association between socioeconomic factors, the methylome and heart failure with Dr Mark Pepin and Dr Adam Wende 1:07:02

3+ y ago1:07:02

1:07:02

On todays episode we speak to Dr Adam Wende and Dr Mark Pepin! We discuss their recent publication which has been all over twitter recently! During the research, they identified an association between socioeconomic factors, the methylome, & heart failure. We discuss all of the motivations, methodological techniques and interesting findings from the…

1
Extrachromosomal circular DNA, chromosome evolution & circular DNA in human disease with the Regenberg Lab (Dr Birgitte Regenberg and Dr Sam Keating) 1:10:37

3+ y ago1:10:37

1:10:37

In today's episode we speak to Dr Birgitte Regenberg and Dr Sam Keating from the Regenberg Lab, University of Copenhagen, about extrachromosomal circular DNA and it's significance in human disease. Circular DNA originates from chromosomes but differs from linear chromosomes as they mostly don’t have centromeres - so if a gene is trapped on a circle…

1
Single Cell Technology Development and Spatial Omics with Dr Cátia Moutinho 1:10:38

3+ y ago1:10:38

1:10:38

We've reached episode 20!!! In celebration of our twentieth episode, we are speaking today to Dr Cátia Moutinho about single cell sequencing and spatial omics - two up and coming techniques that everyone seems to be talking about at the moment. Cátia is Group Leader of the Single Cell Technology Development in the Garvan Institute in Sydney, Austra…

1
The importance of DNA damage in all areas of disease and the potential for personally tailored oncological treatments based on the analysis of DNA damage using machine learning, with Dr Anna Poetsch 1:09:35

3+ y ago1:09:35

1:09:35

This week we speak to Anna Postsch. Anna is a group leader at the biotechnology center at the University Dresden! Her group employs computational techniques and machine learning approaches to assess and model DNA damage and repair processes, mutagenesis and genome editing to develop clinical applications. We also had some interesting conversations …

1
Pharmacogenomics: Barriers and Opportunities to Implementation 26:56

3+ y ago26:56

26:56

1
Cancer epigenetics & the role of Ybx1 in fine tuning PRC2 activity to control embryonic brain development with Dr Myron Evans 1:07:12

3+ y ago1:07:12

1:07:12

On this weeks episode we are discussing Cancer and developmental biology in genomics with Dr Myron Evans! Myron is currently a post doctoral research fellow at St Judes Childrens research hospital in Memphis, Tennesse! Myron discusses with us his journey into cancer biology and shares a unique perspective of life working at a research hospital. He …

1
The Impact of Pharmacogenomics on Precision Medicine 29:17

3+ y ago29:17

29:17

1
The role of Yq-linked genes in fertility and offspring sex ratio with Dr Peter Ellis 1:17:25

3+ y ago1:17:25

1:17:25

We're back after the Easter Break with an extremely interesting episode with Dr Peter Ellis from the School of Biosciences at the University of Kent! Dr.Ellis is a Lecturer in Molecular Genetics and Reproduction at the University of Kent. His research thus far has involved the identification of novel genes on the mouse Y chromosome that affect sper…

1
Metagenomics in the Time of Covid-19: Clinical Metagenomics 25:52

3+ y ago25:52

25:52

1
Metagenomics in the Time of Covid-19: Emerging Pathogens 19:10

3+ y ago19:10

19:10

1
DNA methylation & epigenetic reprogramming during development with Dr Maxim Greenberg 1:13:50

3+ y ago1:13:50

1:13:50

Join us today as we speak to Dr Maxim Greenberg, located at the Institut Jacques Monod in the heart of Paris. IJM is one of the premier institutes for fundamental research in the life sciences in France. Maxim's lab aims to better understand the epigenetic consequences of DNA methylation during a specific window of development which occurs in the f…

1
The Role of Mitochondrial Quality Control Pathways in Familial and Non-Familial Variants of Disease, with David Tumbarello 1:09:29

3+ y ago1:09:29

1:09:29

Join us today as we speak to Dr David Tumbarello, from the University of Southampton, as he talks to us about his dynamic and varied academic career that has taken him from New York, to Southampton, stopping off at a number of places in between!! David's lab currently focuses on understanding the cellular mechanisms and molecular machinery required…

1
Evolutionary genomics- exploring the genomic basis of biological adaptations and transitions with Dr Jordi Paps Montserrat 1:10:31

3+ y ago1:10:31

1:10:31

In today's episode, we speak to Dr Jordi Paps-Montserrat, lecturer in the School of Biological Sciences at the University of Bristol. Jordi did his PhD at the University of Barcelona, before completing his post-doc at the University of Oxford. We talk with Jordi today about his work on evolutionary genomics, and how we can elucidate biological adap…

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