Ep. 36: “Engineered Immune Cell Therapies” Featuring Dr. Leonardo Ferreira

The Immunology Podcast

Guest:

Dr. Leonardo Ferreira is an Assistant Professor of Microbiology and Immunology at the Medical University of South Carolina. The Ferreira lab uses CARs and other engineered immune receptors to dissect how specificity, affinity, and signaling modulate the function of different T cells subsets in tolerance and immunity. He talks about how CAR Tregs could prevent transplant rejection and treat Type 1 diabetes. He also discusses mixing and matching immune cells, the freedom to pursue multiple ideas in academia, and science outreach in Bolivia.

Featured Products and Resources:

• Stay up-to-date with the latest in cell therapy news.
• Download a free wallchart on the production of CAR T cells.

The Immunology Science Round Up

T Cell Nutrient Use – CD8⁺ T cells preferentially consume lactate over glucose in response to Listeria infection.

Blocking Malaria Transmission – A stabilized malaria antigen induces transmission-blocking antibody responses.

A New Metabolic Pathway in Inflammatory Macrophages – Research suggests that L-ornithine could improve LACC1-associated immunological dysfunctions such as arthritis or inflammatory bowel disease.

T Cell Receptor Avidity – Scientists studied how T cell receptor avidity of tumor-specific T cells affected their anti-tumor capabilities using mouse modeling and two melanoma patients.

Image courtesy of Dr. Leonardo Ferreira

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