Ep. 97: “Viral Structures” Featuring Dr. Erica Saphire

The Immunology Podcast

Guest:

Dr. Erica Saphire is President and CEO of La Jolla Institute. Her research explains, at the molecular level, how and viruses are pathogenic and provides the roadmap for medical defense. She talks about the capabilities of cryo-electron microscopy and how it can help illuminate the mechanisms of measles viral fusion. She also discusses her role leading La Jolla Institute. (36:45)

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The Immunology Science Round Up

ILC2s in Pancreatic Cancer – IL-33 induced tertiary lymphoid structures in a mouse model of pancreatic ductal adenocarcinoma. (4:35)

Precursors of Exhausted T Cells – Precursor T cells with at least two distinct phenotypes are preemptively generated regardless of infection outcome. (9:10)

T Cells in Chronic Infections – A population of stem-like CD8⁺ T cells can adapt their differentiation trajectory to either an acute or chronic viral infection. (10:45)

ILC2 Migration in the Gut – Researchers identified a role for immune cells in regulating blood glucose levels in mice. (29:13)

Image courtesy of Dr. Erica Saphire

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