最佳Interlace Podcast播客 (2024)

1
S1826 & INTERLACE 22:49

6d ago22:49

22:49

Discussing two excellent articles from earlier this month.S1826: N-AVD vs. Bv-AVD (DOI: 10.1056/NEJMoa2405888)& INTERLACE: induction chemo prior to concurrent cisplatin/RT in locally advanced cervical cancer (DOI: https://doi.org/10.1016/S0140-6736(24)01438-7)由John Bossaer

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Inavolisib 16:42

13d ago16:42

16:42

A new PIK3Ca inhibitor is approved for breast cancer.由John Bossaer

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Autumnal (2024) AML Updates 13:48

20d ago13:48

13:48

Reviewing 3 recent AML publicationsDouble-Dauno (90 mg/m2 vs. 60 mg/m2): https://doi.org/10.1200/JCO.24.00235AML60+ Risk Stratification: https://doi.org/10.1200/JCO.23.02631Decitabine-Ven as bridge to Allo HSCT: https://doi.org/10.1016/S2352-3026(24)00241-2由John Bossaer

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MSI-High Rectal Cancer Treatment 10:03

27d ago10:03

10:03

MSI-high/MMRd rectal cancer treatment guidelines are being re-written. A brief synopsis of why treatment guidelines are changing so quickly in this space.Also, listeners helped out in explaining the ribociclib storage & stability change. Hint: https://www.novartis.com/news/novartis-implements-manufacturing-adjustments-ribociclib-ensure-alignment-la…

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NATALEE + a slew of FDA updates 16:39

1M ago16:39

16:39

FDA has been busy the last week approving:-ribociclib x 3 years in high risk stage II & III breast cancer based on the NATALEE trial as well as a new storage requirement-osimertinib indefinitely following chemoradiation in stage III EGFR-mutated NSCLC-amivantamab + chemotherapy following progression on osimertinib (Mariposa-2)-a subcutaneous formul…

1
ESMO 2024 22:17

1M ago22:17

22:17

Recapping just some of the notable data coming out of ESMO 2024:-Final OS results from Keynote-522 (perioperative pembrolizumab in TNBC)-AMBASSADOR (adjuvant pembrolizumab in bladder cancer) -NIAGRA (perioperative durvalumab in bladder cancer)-ADRIATIC (discussed on ASCO recap Pod, but publication now available)-LEANOX (impact of lean body mass adj…

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Doxorubicin + Trabectedin 17:00

2M ago17:00

17:00

LMS04 final OS results are published for doxorubicin + trabectedin in Leiomyosarcoma. Plus, a natural experiment of what happens in small cell lung cancer during an IV etoposide shortage. Finally, a nice paper provides some examples of how oncology pharmacists can bridge the care gap between oncology and primary care.LMS04: https://www.nejm.org/doi…

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Chapter 1. Doses Matter 22:48

2M ago22:48

22:48

This is chapter 1 of a keynote address from summer 2024 on putting together the pieces of oncology pharmacy - with an emphasis on how our knowledge of drug dosing changes with time.Video/slides available at YouTube: https://youtu.be/1Oae8AV5Af4由John Bossaer

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Cross-Trial Comparison Don'ts 19:31

2M ago19:31

19:31

We all know we aren't supposed to make cross-trial comparisons, but it happens anyway. So, let's compare FLARUA2 (osimertinb + chemo) and the newly FDA-approved MARIPOSA regimen (lazertinib + amivantamab) to see what we can (and can't) take away from such a dangerous cross-trial comparison.由John Bossaer

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Olanzapine For MEC 14:17

3M ago14:17

14:17

A mixed bag of Phase III results for using olanzapine with moderately emegotenic chemotherapy (MEC).Inui, et al: https://doi.org/10.1200/JCO.24.00278Ostwal, et al: doi:10.1001/jamanetworkopen.2024.26076由John Bossaer

1
Afamitresgene Autoleucel & Vorasidenib 12:29

3M ago12:29

12:29

A new cellular therapy is approved for synovial sarcoma and the anticipated approval has occurred for the dual IDH1/IDH2 inhibitor, vorasidenib.由John Bossaer

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Perioperative ICI Trial Design & Blood Test Screening For Colorectal Cancer 15:47

3M ago15:47

15:47

FDA appears to change its stance on evaluating perioperative (adjuvant followed by neoadjuvant) ICI study designs in NSCLC.Also, a simple blood test is approved to detect colorectal cancer, but there are several limitations compared to colonoscopy.由John Bossaer

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The Auto Transplant Breast Cancer Scandal 15:28

3M ago15:28

15:28

Did you know high-dose chemotherapy with autologous stem cel rescue was a "standard" breast cancer treatment ~30 years ago? This story involves changing practices based on Phase II data and outright clinical trial fraud, and retractions of publications.On-site review of Bezwoda study: https://doi.org/10.1016/S0140-6736(00)90024-2Oral History: https…

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Vacation Reflections 9:24

3M ago9:24

9:24

Reflections from vacation on 1) How similar the chef training experience on The Bear mirrors some pharmacy residency training and 2) being a resource to family/friends with oncology questions.由John Bossaer

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June '24 Updates & ATOPP Travelogue 14:19

4M ago14:19

14:19

Running through recent updates on epcoritamab, adagrasib + cetuximab for colorectal cancer, endometrial cancer, adjuvant dabrafenib/trametinib melanoma follow-up data, and topical capsaicin for delayed CINV.Also, a brief travelogue on my inaugural trip to ATOPP (advanced topics for oncology pharmacy professionals) Summit.…

1
MARIPOSA 10:20

4M ago10:20

10:20

The MARIPOSA study suggests there may be a new preferred first line regimen (amivantamab + lazertinib) for metastatic EGFR-mutated NSCLC, as this regimen improved PFS compared to osimertinib.由John Bossaer

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ViPOR 13:38

4M ago13:38

13:38

An experimental regimen for DLBCL piques my interest.VenetoclaxibrutinibPrednisoneObinutuzumabRevlimid (lenalidomide)Link: https://www.nejm.org/doi/pdf/10.1056/NEJMoa2401532由John Bossaer

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Imetelstat, Targeting Telomerase 12:11

5M ago12:11

12:11

A new drug is approved for MDS. While some will likely benefit from this new agent, the more enticing news is that inhibiting telomerase may be an attractive target for many malignancies.由John Bossaer

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ASCO 2024 25:08

5M ago25:08

25:08

Lots and lots of updates from the past weekend's ASCO annual meeting.1. ADRIATIC (consolidation durvalumab in limited stage SCLC)2. NADINA (neoadjuvant Nivo/Ipi in stage III melanoma)3. *NICHE-2 (neoadjuvant Nivo/Ipi in dMMR colon cancer)4. CheckMate 8HW (Nivo/Ipi in dMMR metastatic colon cancer)5. TRANSMET (liver transplantation in colon cancer wi…

1
Updated ASCO-ONS Antineoplastic Safety Standards 13:16

5M ago13:16

13:16

ASCO & ONS (along with pharmacist representation) released updated safety standards for preparing, administering, and monitoring chemotherapy. Look for a calendar invitation to review your site's policies soon.Link: https://doi.org/10.1200/OP.24.00216由John Bossaer

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Tarlatamab 10:12

5M ago10:12

10:12

A new drug for small-cell lung cancer, a bispecific, targeting DLL3 on small-cell lung cancer and CD3 on T-cells is FDA approved. But, infigratinib's FDA approval for cholangiocarcinoma is withdrawn.由John Bossaer

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QT Prolongation In Oncology 14:56

6M ago14:56

14:56

QT interval prolongation is a common hurdle to taking care of cancer patients. We dive into what QT interval prolongation is, why it matters, risk factors, and prevention/management strategies.由John Bossaer

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Pro-MACE-CytaBOM 9:56

6M ago9:56

9:56

The non-Award Winning series of Landmarks in OncoPharm returns to discuss a Next Big Thing in NHL that wasn't any better than plain old CHOP.From April 1993, it's Pro-MACE-CytaBOMLink: https://www.nejm.org/doi/full/10.1056/NEJM199304083281404由John Bossaer

1
Tisotumab Vedotin, HD Mtx In CNS Lymphoma & Class III BRAF Mutations 9:37

6M ago9:37

9:37

Tisotumab vedotin garners a regular FDA approval for metastatic cervical cancer with OS benefit data.A lingering question that demands a focused RCT: What is the optimal dose of methotrexate in primary CNS lymphoma? I'm glad I'm not the only one with this question: https://doi.org/10.1177/10781552231176754What, some BRAF mutations in colorectal can…

1
Late April Updates 19:55

6M ago19:55

19:55

Lots of recent updates to cover this week...1. Adjuvant pembrolizumab of RCC demonstrates OS improvement in NEJM publication (DOI: 10.1056/NEJMoa2312695)2. Yet adjuvant nivolumab did not demonstrate OS improvement in the adjuvant setting. There may be a few reasons for this (https://doi.org/10.1200/JCO.2024.42.4_suppl.LBA358)3. A cytokine-fusion pr…

1
NSCLC In A Nutshell 11:37

6M ago11:37

11:37

Arguably, the most anticipated release of 4/19/24由John Bossaer

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HOPA '24, Site Agnositc T-DXd, & ALINA 14:10

7M ago14:10

14:10

What I learned (or relearned?) at HOPA's 2024 Annual Conference: updates in Neuro Oncology, fedratinib toxicity, and bispecific antibodies in multiple myeloma.Also, fam-trastuzumab deruxtecan (T-DXd) garnered a site-agnostic approval for HER2 amplified solid tumors.Finally, the ALINA study, adjuvant alectinib in ALK+ NSCLC, was published in this we…

1
Tumor Lysis Syndrome 15:29

7M ago15:29

15:29

Tumor Lysis Syndrome (TLS) is a foundational topic for all oncology clinicians. We discuss the what, the why, prevention, and treatment.由John Bossaer

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Eps. 11: Protecting Your Flock, The Pros and Cons of Each Guardian 58:56

7M ago58:56

58:56

There are many ways to protect your flock! Alpaca, llama, donkeys, pigs, LGDs... what do you use? I go through my experience with each of these and the pros and cons of each. Sheep need protection, what will you decide on? The Desert Shepherdess Workbook is on sale! It is not only for the desert. There is so much to consider! Let me help you star o…

1
Eps. 10: Sheep Start Up Cost 34:48

7M ago34:48

34:48

Are you ready to start your sheep journey?? I break down the cost of getting started from the actual sheep to daily upkeep! This is a major consideration. Sheep are for the long run. My Workbook on Getting Started with Sheep is on SALE! Grab it while it's available at such a low price! https://stan.store/Desert_Shepherdess…

1
Updates In RCC, Pancreatic Cancer, And Skin Cancer In SOT 13:44

7M ago13:44

13:44

Discussing four papers that caught our eyes from the last few weeks:Pazopanib vs. placebo following metastatectomy. Always concerning when placebo has an OS advantage.ECOG-ACRIN E2810: https://doi.org/10.1200/JCO.23.01544Gemcitabine vs. Gem + Paclitaxel (Taxol) in pancreatic cancer patients after FOLFIRINOX: https://doi.org/10.1200/JCO.23.00795An R…

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Ep. 9: Using Wool In Your Garden 30:52

7M ago30:52

30:52

Gardening With Wool! You don’t have to know how to spin or felt, you don’t need to know how to make all these things from wool. You can simply add raw wool into your garden and reap the benefits! In todays episode, I talk about many great properties that wool bring to your soil and plants! I have been using it in my garden for a few years and my so…

1
Ep. 8: Preparing From Lambing Season 1:04:57

7M ago1:04:57

1:04:57

Lambing season is my favorite! New life. Fresh milk. I look forward to it all year but I would be lying if I told you it was always sunshine and rainbows. The best way to succeed is to be prepared. Here is what I keep in my lambing kit! Veterinarian and/or Mentor Number Jugs Heat Source Gloves Scissors Coconut Oil Halter/Lead Towel Digital Scale Pr…

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Ep. 7: 5 Things To Consider For Sustainability and Reduce Burnout 29:04

8M ago29:04

29:04

Do you want to simplify your farm using sheep? Let me help you defeat burnout! 5 Things to Consider for Sustainability Time Resorces Present Time Breed Minerald amd Vitamins Grab by Desert Shepherding Workbook to guide you to success with sheep! Don't miss it, it's ON SALE! Did you know you can now have a 1:1 Video Call with me to discuss your goal…

1
Colon Cancer Screening Wars 11:35

8M ago11:35

11:35

Two recent publications suggest more people may be choosing non-colonoscopy screening practices in the future. One is a new stool DNA test, while the other is a blood test.How do they compare to the gold standard of colonoscopy?Cell-free DNA blood test: DOI: 10.1056/NEJMoa2304714Next generation stool DNA test: DOI: 10.1056/NEJMoa2310336…

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Ep. 6: Finding The Purpose Of Sheep 22:59

8M ago22:59

22:59

In this episode I share the top 5 purposes for sheep! *Pet *Wool *Meat *Market *Dairy What is the purpose of your sheep? Are you using your sheep to their full potential?? Sheep Milk Morning Drink *Sheep milk *Raw Egg *Chia Seeds *Turmeric *Cloves *Cinnamon *Honey Blend all together for a protein packed yummy drink that will keep you satisfied for …

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Ep. 5: The Blackbelly Barbados Sheep 19:37

8M ago19:37

19:37

The Blackbelly Barbados are wonderful meat sheep! If you're looking for a disease and parasite resistant meat sheep that is regal and beautiful, Barbados may be your fit! IG: @desert.shepherdess FB: Desert Shepherdess https://stan.store/Desert_Shepherdess由Marissa Chayil

1
Bladder Cancer Updates 12:46

8M ago12:46

12:46

EV-302 is finally published, and you have to squint to find any major critiques. Enfortumab bedouin + pembrolizumab fully arrives as a standard 1st-line regimen of advanced urothelial cancer.Also, nivolumab gets a 1st-line FDA approval for urothelial carcinoma in conjunction with cisplatin + gemcitabine based on CHECKMATE-901.…

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Ep. 4: A Veterinarian, A Friend or Facebook, Who Will You Call? 28:44

8M ago28:44

28:44

When a concern arises, who will you go to for advice? In todays episode we will discuss some options for who to go to and the pros and cons of a veterinarian, a mentor or Facebook group. I am excited for this episode because this can save a life of a flock member! It can help you not be overwhelmed when trouble comes up. https://stan.store/Desert_S…

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Ep. 3: The Difference Between Owning Sheep and Being A Shepherd 35:53

8M ago35:53

35:53

In todays episode, we will talk about what it means to be a shepherd. Does it just mean owning sheep? There is so much that goes into being a true shepherd. We may not trek the wilderness with our sheep but we could still build a relationship with them. My workbook is on sale, still! Grab it at this price while you can! I will help you be confident…

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Ep. 1: 5 Reasons Why I Am Rebranding the Desert Shepherdess 15:50

8M ago15:50

15:50

In todays episode, I am sharing the 5 reasons I decided to rebrand and relaunch my podcast! 1. Sheep are gaining popularity 2. I wanted an easier to find title 3. Focusing on what I know; the desert 4. Simplicity 5. I want you to have a positive experience with sheep You can find me on Instagram: @desert.shepherdess Facebook: Desert Shepherdess You…

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Ep. 2: Ways to Save Money and Lower Feed Bill with Sheep 16:31

8M ago16:31

16:31

Specific breeds can save you money! Who doesn't want to lower their feed bill and over all cost? You can find me on: instagram: @ desert.shepherdess facebook: Desert Shepherdess Grab my FREE list of desert breeds and my Desert Shepherding Workbook! Start off on the right foot! https://stan.store/Desert_Shepherdess…

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Ep. 0: Trailer 0:58

8M ago0:58

0:58

My mission as the Desert Shepherdess is to help modern day shepherds attain healthy sheep based on where they are you what they have at the moment. I give tactical solutions to be frugal, using every bit of the sheep to the best of their ability. Sheep were the first domesticated animals, we can learn a thing or two about the old ways! We have beco…

1
SPARED & D-TORCH 12:24

8M ago12:24

12:24

Two nice studies have been recently published in the supportive care realm.SPARED asks if we can omit dexamethasone on days 2-4 following cisplatin-based chemotherapy.D-TORCH asks if topical diclofenac can prevent capecitabine-induced hand-foot syndrome.SPARED: https://doi.org/10.1038/s41416-023-02493-7 D-TORCH: https://doi.org/10.1200/JCO.23.01730…

1
Lifileucel & FLAURA2 Updates 17:27

8M ago17:27

17:27

An exciting new cellular therapy, lifileucel, is approved for metastatic melanoma. The FLAURA2 trial of osimertinib + chemotherapy has led to an FDA approval, but questions remain about a possible new standard of care. And a few minor updates on tepotinib.由John Bossaer

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NAPOLI 3, POUT, & Ivosidenib - Azole DDIs 15:19

9M ago15:19

15:19

New updates on metastatic pancreatic cancer (NAPOLI-3), upper tract urothelial cancer (POUT), and the drug-drug interaction between ivosidenib and azole antifungals.NAPOLI 3: https://doi.org/10.1016/S0140-6736(23)01366-1POUT (final OS): https://doi.org/10.1200/JCO.23.01659Ivosidenib Azole Antifungal DDIs: https://doi.org/10.1002/cncr.35251…

1
Small Cell Carcinoma, Prostate Edition 7:53

9M ago7:53

7:53

You know about small cell lung cancer, but let's talk about small cell carcinoma of the prostate.由John Bossaer

1
Rethinking Some Fundamental Considerations 15:41

9M ago15:41

15:41

In oncology we are always asking questions about which treatment option is best. And that focus on the next best treatment may prevent us from rethinking some fundamentals of current practice. Three recent studies illustrate this and made me ask:Do we need a Port or PICC for every testicular cancer patient?Study: https://doi.org/10.1200/OP.23.00580…

1
Jan 2024 Updates... 15:25

9M ago15:25

15:25

...on FDA approvals for belzutifan for RCC, pembrolizumab + cisplatin/RT for cervical cancer, erdafitinib (FGFR3 alterations only) for bladder cancer.Plus, early morning ICIs (https://doi.org/10.1016/j.ejca.2024.113571)&FLAG-Ida-GO in AML from NCRI AML 19 (https://doi.org/10.1200/JCO.23.00943)由John Bossaer

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Development Of Generic Lenalidomide with Dr. Ryan Beechinor 34:39

10M ago34:39

34:39

Special guest Ryan Beechinor joins the pod to discuss his recent paper on the obstacles in the development of generic lenalidomide. It's a fantastic read, and this episode will be a fantastic listen!Link: https://doi.org/10.1016/j.jcpo.2023.100446由John Bossaer

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