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This is a podcast made by scientists for scientists, to help you save time so you can conduct better research. For a given month, we sort the abstracts of the latest primary research articles on Alzheimer's disease into separate categories. We then summarize them for you to enjoy on the bus, on your jog, or in the lab. We hope you find our podcast useful and accessible. For questions or feedback, contact us at amindrpodcast@gmail.com .
 
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Today, we talk all about neuroimaging, with 7 papers that use various imaging modalities in humans, animals, and computational modeling, to study how the brain changes in Alzheimer’s disease. Tune in to learn more! Sections in this episode: Hippocampus (3:50) Hypothalamus (8:15) Cortical regions (10:29) Nucleus basalis (15:57) Pineal gland (18:40) …
 
Anusha brings you another episode of AMiNDR featuring literature published in October 2022. In this episode, you'll hear 12 papers that converge on the topic of treatments that target neurotoxicity. This episode is poised to leave you feeling hopeful about the various treatment avenues to be pursued so be sure to tune in! Sections in this episode: …
 
In today's episode, there's a big focus on sleep in Alzheimer's disease, as well as other clinical and pharmacological studies that dive into the cognitive and behavioural deficits. We even have one paper that looks into character strengths in AD, so definitely join Judy and follow along in this unique episode from our October 2022 series! Sections…
 
In this episode, Elyn takes you through 13 papers from October 2022 published on vascular contributions to Alzheimer disease. It's quite the journey through mechanistic mouse studies, neuroimaging studies, and a few studies assessing treatments targeting the vasculature, which all paint a pretty convincing picture of the importance of the cerebrova…
 
Kick off the new year with Ellen, who tells you all about synaptic transmission in Alzheimer's disease in this episode. You'll hear about 5 papers published in October of 2022 on synaptic transmission, ranging from research on whole brain networks all the way down to individual proteins. -------------------------------------------------------------…
 
We have one last episode for you to wrap up 2022! In this episode, Naila will guide you through 11 papers published in August 2022, covering a range of way researchers are working on preventing or treating aspects of Alzheimer's disease through non-pharmacological therapies. You'll hear about cognitive training tools, the effects of disrupting circ…
 
In this month's episode of AMiNDR, Cassi recaps papers on APOE published in August 2022. Cassi just defended her dissertation where she studied immunometabolism in the context of APOE. She starts with cells, moves to mice, and finishes with human research studies. -------------------------------------------------------------- To find the numbered b…
 
Today, we have papers on behavioural and cognitive changes in Alzheimer’s disease. We’ve got our usual sections such as rodent models and sleep, but we also have some new topics, including cognitive reserve and even a paper on virtual reality. You’re in for a treat! Sections in this episode: Behavioural Changes (2:28) Cognitive Changes (11:10) ----…
 
After a bit of a break, Elyn is excited to be back with the latest in the field of vascular contributions to Alzheimer disease. With the current (and constant) controversy in the field about targeting amyloid as a disease-modifying therapy, perhaps it's time we turned to a new target: the vasculature. Tune in for an overview of papers published in …
 
To kick off our series on August papers, we will talk all about different ways that synaptic transmission may be affected in Alzheimer's disease, with 6 research papers that use either cell models, animal models, or human patients. Stay tuned! Sections in this episode: Cortical signaling in rodent models (3:15) New AD models (8:32) Biomarkers of ne…
 
In Part 2 of Cognitive and Behavioural Changes, Naila covers 8 papers on neuropsychiatric, social and cognitive symptoms linked to Alzheimer's disease, and their implications for diagnosis and disease management. You'll learn about the links between AD and depression, the importance of social networks, and machine learning methods for identifying i…
 
In this episode, Naila will guide you through 14 papers on potential neuroprotective factors to mitigate the risk of Alzheimer's disease, non-pharmacological interventions that could directly target Alzheimer's pathology, and strategies for symptom management. You'll hear about the role of embodiment in memory, light therapy technologies, the role …
 
This is an episode all about targeting synaptic and neuronal heath in Alzheimer's disease. Anusha will cover in silico, in vitro, and in vivo studies of candidate compounds that target neuroprotection and neurogenesis. Be sure to check out this paper to stay up to day on the latest preclinical therapeutics being tested. Sections in this episode: In…
 
In this episode exploring the effect of allelic variation of APOE, we review abstracts from large human GWAS studies all the way down to new mouse models expressing the human ApoE proteins. There are some particularly interesting abstracts on protection from cognitive decline despite having a risk allele for Alzheimer's disease. These are great stu…
 
Part 1 of our cognitive and behavioural changes category will focus on papers that explore behavioural and sensory processing deficits in AD. Topics range from motor impairments to visual and olfactory processing in both human patients and mouse models of AD. If you're curious about how AD patients process the facial expression of pain, then this i…
 
Elyn is back to discuss the latest research on vascular contributions to Alzheimer disease! Tune in to hear about proteomic changes with amyloid deposition in the vasculature, new therapeutic avenues, and a more detailed account of the perivascular space. If you're interested in factors beyond amyloid and tau in the Alzheimer disease pathology, thi…
 
We are kicking off our July 2022 series of AMiNDR with this episode and are so glad you are tuning in. If you’re interested in changes to neuronal function in AD, we’ll be covering the entire spectrum in this episode. Starting big with network changes, we scale all the way down to molecular changes that may underlie AD pathology, so if that’s what …
 
Today's episode includes 15 papers on non-pharmacological treatments and complementary therapies for AD. Naila will take you through research published in June 2022 on an array of topics including olfactory training, beer, choir participation, light therapy, and transcranial magnetic stimulation. You'll be treated to research on both the human and …
 
We promised you we would be back with more on clinical assessment for Alzheimer’s disease, and here we are to deliver. Stick around to hear about papers published in June 2022 on validating variations of the Montreal Cognitive Assessment, tracking Activities of Daily living, and digital tools for assessing cognition. Our harvest yielded 7 abstracts…
 
Approximately, one in every five people you know, has a copy of the largest genetic risk allele for late-onset Alzheimer's disease called apolipoprotein E4 (APOE). In this episode, Cassi discusses papers from June 2022 about APOE and covers human subjects research, pathology related to E4 risk, and mechanisms. Sections in this episode: Human Subjec…
 
In this episode, Joseph covers papers published in June 2022 on GWAS studies, transcriptomics, genetic and genomic studies and the like on Alzheimer’s disease. Stay tuned! Sections in this episode: Genetic & Disease Overlaps (2:15) RNA & Transcriptomics (5:10) Genetic Testing (10:25) GWAS Studies (15:24) Specific Genes (21:04) Extra (28:55) -------…
 
Anusha brings you 12 papers today on the development of treatments that target neuroprotection in Alzheimer's disease. This includes a range of research models, from in silico and drug discovery studies, to rodent models of AD. Enjoy! Sections in this episode: In Silico and Drug Discovery Studies (2:27) Testing Phytochemicals in AD Rodent Models (7…
 
This episode contains a whole range of topics in cognitive and behavioural changes in AD! Tune in as Judy covers a variety of papers published in June 2022, spanning from from sensory processing in mouse models to antidepressants in human patients. There's bound to be something that piques your interest! Sections in this episode: Studies Using Mous…
 
You are here, with us, right now, about to get the updates you eagerly wait for every month in Alzheimer’s disease research. A whole episode dedicated to assessing neurocognitive domains for screening and diagnostics. Learning and memory? Executive function? Perceptual and motor skills? You got it! 7 abstracts published in June 2022, nicely package…
 
Ever thought there was more to Alzheimer disease than the plaques and tangles? You've come to the right place. Join Elyn for a guide through the latest research on vascular contributions to Alzheimer disease. June 2022 brought lots of new insight into how vascular hallmarks interact with the classic AD hallmarks to influence cognition, emphasis on …
 
We are kicking off our June 2022 series of episodes with this short and sweet episode. Anusha takes a look at papers published on the subject of changes to synaptic transmission and neuronal excitability in Alzheimer’s disease. If you're interested in bridging the gap between changes to neuronal function and behavioural consequences, this episode i…
 
Elyn is back with a short and sweet episode on the latest research on vascular contributions to Alzheimer disease! Tune in for a quick recap of May 2022 research, and a disease perspective a bit more lively than the classic amyloid cascade hypothesis! Clinical Studies (3:53) Preclinical Studies/Methology (12:41) ------------------------------------…
 
Anusha is excited to guide you through 12 papers published in May of 2022 that all test different treatment options for Alzheimer’s disease, preclinically. She will cover topics like discovery and development of agents that confer neuronal and synaptic protection or target neuronal function directly. This episode is sure to leave you feeling hopefu…
 
In this exciting episode, Judy goes over papers published in May 2022 on the latest research involving cognitive, behavioural and clinical changes in AD. Subjects include sensory processing, mouse models, sleep, and many more! Sensory Processing (1:45) Mouse Models (5:44) Clinical Treatments (8:34) Sleep (12:59) Other (17:29) ----------------------…
 
In this episode, Joseph is back to go over papers published in May 2022 on GWASs, genetics or any other genetics-focused work. Topics include GWAS's, tool development, gene discovery, and social performance-based genetic studies! GWAS and Polygenic Risk Scores (2:20) Cognitive & Social Genetic Studies (8:42) Tool development (11:46) Gene Discovery …
 
Welcome welcome! This episode was made for you if you are interested in geriatrics, neurology, or cognitive testing in general, as we will go through the latest publication on clinical assessment of cognitive decline. That’s right, 9 papers published in May 2022 on testing neurocognitive domains for the screening or diagnosis of mild cognitive impa…
 
AMiNDR is back and excited to bring you more literature on Alzheimer’s Disease. In this episode, we’ve got papers published in May of 2022 on the subject of changes to synaptic transmission and neuronal excitability. Anusha covers subjects like calcium homeostasis, synaptic function, and how to translate findings to humans and human models, so join…
 
In the final episode of the March 2022 series, Naila takes you through 18 papers on non-pharmacological strategies for preventing or treating Alzheimer's disease. You'll hear the latest from animal studies on exercise, learn about the potential benefits of brown rice, pet ownership and yoga, and be guided through a number of techniques that are bei…
 
Welcome back for the second of a 2-part episode on the clinical assessment of Alzheimer’s disease, based on abstracts published in March 2022! You will hear about the evaluation of traditional and digital tests for their potential to help us detect AD and distinguish it from MCI. Also on the menu, a few papers on markers of cognitive decline that m…
 
This is our monthly update on clinical assessment of Alzheimer’s disease, based on abstracts published in March 2022! This is the first of a 2-part series on the matter, where we bring together ways to assess cognitive function by looking at one neurocognitive domain, such as learning and memory, language, perceptual-motor skills, and even by looki…
 
Another 12 papers published in March of 2022 awaits you. This episode is all about treatments that target neuroprotection to treat AD. The papers model it by inducing cytotoxicity in the brain, either with molecules like amyloid beta or genetic mutations. Anusha is excited to guide you through promising treatment options, are you excited too? Secti…
 
Ease in to our March 2022 series with 8 papers published on the subject of synaptic transmission in Alzheimer's Disease. Anusha will highlight changes to connectivity and ones caused by APP and Tau proteins so check out this episode to bridge the communication gap in your brain too! Sections in this episode: Synaptic Connectivity Changes (1.44) APP…
 
In February of 2022, 8 papers were published on the topic of using neuroprotective compounds as treatment for AD. Anusha will guide you through these papers exploring the entire drug discovery pipeline, from discovery to clinical trials. Sections in this episode: Drug Discovery (2.01) Drug Development (4.59) Clinical Trials (11.58) ----------------…
 
February 2022 was full of abstracts using unique therapeutic approaches to target Alzheimer's disease. Cassi presents abstracts on both naturally-occurring and pharmaceutical compounds used to treat various neurodegenerative pathology and symptoms. Sections in this episode: Microbiome (1:55) NF-kappaB signaling pathway (6:12) Sexual dimorphism (11:…
 
In today's episode, Naila will guide you through 19 papers from February 2022 on the prevalence and incidence of Alzheimer's disease in various study populations, social determinants of health, as well as environmental and lifestyle factors that may influence the risk of dementia. Part 2 will be available as a bibliography, which you can find in ou…
 
Welcome back for the continuation of our segment on clinical assessment. You heard about testing specific neurocognitive domains in part 1, and here we’re back to cover abstracts that look at the big picture in assessing cognitive function. We’re presenting 8 abstracts published in February 2022, perfect for you if you’re interested in tracking cog…
 
If you wanted to detect and diagnose Alzheimer’s disease, or assess disease progression, what aspects of cognition would you focus on? In other words, what capabilities would you test to decide if someone is indeed experiencing cognitive decline, had Alzheimer’s disease, or another type of dementia? And what tools could you use? Stay with me to hea…
 
This month's episode covers a range of interventions and non-pharmacological treatments that could help prevent or live with AD. Naila will take you through the various mechanisms underlying the impact of different lifestyle interventions, the potential therapeutic effects of exercise, what mushroom consumption and ketogenic diets might have to off…
 
Ever wondered how amyloid deposited in cerebral vessels might affect cerebrovascular reactivity? Or how the culture time of iPSC-derived brain microvascular endothelial-like cells changes their phenotype? Well, you've come to the right place. Elyn will take you through all this and more as she emphasizes the importance of cerebrovascular health in …
 
In Part 2 of epidemiological studies published in January 2022, we'll focus on the association between cardiovascular health, diabetes and Alzheimer's disease. Naila will guide you through the latest research on how things like blood pressure, body mass index and insulin resistance are related to dementia and to AD pathology. Sections in this episo…
 
In Part 1 of this 2-part episode on epidemiological studies published in January 2022, Naila will take you through 12 papers on risk and protective factors linked to Alzheimer's disease, ranging from stressful life events, to exposure to greenspace in one's neighborhood, to sleep troubles and testosterone. We cover a lot of ground in this episode, …
 
With her first episode covering papers from 2022, Elyn is back with a lot of new and interesting findings implicating blood-brain barrier dysfunction in Alzheimer disease. Tune in to hear about this and much more in this longer episode covering 15 papers published in January 2022! Sections in this episode: Clinical Insights - Vascular Risk Factors …
 
Pssst. Did you hear that 14 papers were published in January of 2022 on treatments targeting synaptic and neuronal protection in Alzheimer's disease? Anusha has you covered with papers targeting amyloid-beta-induced cytotoxocity, demyelination, and cognitive dysfunction in animal models. Sections in this episode: Treatments using stem cells (2.18) …
 
What information do grey and white matter tell us about mild cognitive impairment vs. Alzheimer's disease? Enjoy this episode in which Christy goes over study findings from 12 papers published in January 2022 on the topic of structural brain changes related to AD. Sections in this episode: Gray and white matter changes (2.25) Correlations of struct…
 
Today's episode will take you all the way from the molecular to the human level in 16 papers on non-pharmacological approaches for preventing or treating Alzheimer's disease. Naila will guide you through the latest research on exercise in AD mouse models, nutritional supplements that could decrease the risk of AD, the potential therapeutic effects …
 
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