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This is a podcast made by scientists for scientists, to help you save time so you can conduct better research. For a given month, we sort the abstracts of the latest primary research articles on Alzheimer's disease into separate categories. We then summarize them for you to enjoy on the bus, on your jog, or in the lab. We hope you find our podcast useful and accessible.
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Another series of AMiNDR kicks off with this episode. Anusha takes you through 7 papers published in January 2024 targeting neuroprotection in AD. If you'd like to hear about potential compounds that could reduce neurodegeneration in Alzheimer's disease, this is the episode for you. Testing for neuroprotection in cell lines (2:57) Testing for neuro…
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Another special episode to help kick off our return! In what we hope to be a recurring special series, an interview with members in our scholarly community on navigating the multiple facets of life as a scientist. In the first episode, host Kevin Nishimura interviews one of our own Joseph Liang on his personal journey to and through graduate school…
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In today's episode, Naila provides an overview of 14 articles published in November 2023 on non-pharmacological interventions for AD. You'll hear about cognitive training, music therapy, chair yoga, providing support to caregivers, and a range of neural stimulation techniques. Enjoy! Cognitive and Social Factors (2:26) Lifestyle interventions (13:4…
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Join us as we cover a set of papers published in November 2023 on treatments targeting cholinergic transmission in Alzheimer's disease. In this episode hosted by Christy, we will go over various topics, from drug discovery using synthesized compounds to drug testing of plant extracts, as well as improving drug delivery through the blood-brain barri…
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As we get back up to speed on our regular episodes, we thought we'd treat you (and ourselves) to something out of the ordinary: a conversation on how visual storytelling can shape how we think - and feel - about Alzheimer's disease. Host Naila Kuhlmann had the pleasure of interviewing Gina Martin, who founded the Bob and Diane Fund to support and p…
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Hello listeners, it’s been a while since we last released an episode but we are back with another series here at AMiNDR bringing you a synopsis of publications on Alzheimer’s disease (AD) research on various topics that were released in November of 2023. In this episode, Anusha takes you through 11 papers testing potential neuroprotective agents fo…
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If you’re interested in hearing about the impact of hearing aids on quality of life in AD patients, or how having a stable life partner can slow down the progression of dementia, tune in to this episode on the latest in cognitive and behavioural research in Alzheimer's disease! Judy will cover 9 papers on sleep, depressive symptoms and sensory proc…
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In today's episode, Naila provides you with an overview of 10 paper published in February 2023, on non-pharmacological therapies for Alzheimer's disease. You'll learn about a virtual reality intervention targeting anxiety, the signaling pathways underlying the potential benefits of acupuncture, the challenges of implementing new interventions, and …
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This short and sweet episode kicks off the February 2023 series, highlighting studies all the way from worms to humans. Anusha will take you through 9 papers that converge on targeting neuroprotection in Alzheimer's disease. If you're interested in learning about implicated pathways or potential therapeutics, this episode is sure to whet your appet…
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Elyn's back with more insight from the field on how blood vessel health impacts brain health. Tune in for a journey through mechanisms underlying increased risk from "vascular risk factors" like hypertension, diabetes, and atrial fibrillation, lots of neuroimaging studies providing clinical insights, and several interesting novel therapeutic avenue…
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This episode covers some papers from January 2023 on treatments focused on repairing the neurotransmitter imbalance in Alzheimer's disease. We hope you enjoy listening as Christy summarizes this exciting research—from the discovery of new therapeutics to the synthesis of drugs. Sections in this episode: Drug Screening (3:37) New Drugs (7:00) Synthe…
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In today’s episode of AMiNDR, Ellen will tell you all about the functional connectivity of different networks in the brain, and changes to brain structure and volume in Alzheimer’s disease. This includes how these changes in the brain relate to cognitive changes, behavioural symptoms, and other neuropathological markers. There are many fascinating …
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Naila covers 11 papers from January 2023, with a focus on a variety of stimulation techniques. You'll get a smattering of new research from humans to mice to flies, and from brain imaging to computer simulations to molecular mechanisms. Enjoy! Sections in this episode: Complementary therapies (2:55) Current and magnetic stimulation (7:25) Electroac…
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We’ve got a whole variety of studies in this January 2023 episode, spanning from sensory processing, to sleep, and even to depressive symptoms. Tune in to learn more about the latest in cognitive and behavioural changes in Alzheimer's disease! Sections in this episode: Sensory Processing (2:28) Sleep (7:30) Balance (14:14) Depression (17:00) Other …
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In this episode, we’ll be covering papers that were released in January 2023 that target neuronal and synaptic protection in Alzheimer’s Disease. If you’re interested in the preclinical testing of novel therapeutics and delivery methods, this is the episode for you! Sections in this episode: Novel Therapeutics Targeting Neuroprotection (4:53) Novel…
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We are diving in to all things neurotransmitters and synaptic signaling to kick off the January 2023 series. You'll hear about dopamine, noradrenaline, prion proteins, a new 3D cell culture model, and more, in today's episode. Enjoy! Sections in this episode: Monoamine Neurotransmitters (3:50) Glutamate (9:18) Acetylcholine (15:51) Synaptic Protein…
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Welcome our new host, Anelya, who covers 12 papers on the role of immune system and glia in Alzheimer’s disease. The first half of this episode will focus on potential targets for the treatment of Alzheimer’s disease, followed by the disease-associated inflammatory mechanisms. Part 2 will be released as a bibliography. We hope you find this episode…
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Ellen brings you summaries of 8 abstracts from November 2022, all about functional connectivity and imaging in the context of Alzheimer's disease. There are a variety of brain regions covered in today's episode, including cortical regions, subcortical structures, and the hippocampus. Spanning studies in both humans and animals, this episode is sure…
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For today's episode, Naila is back to take you through 20 papers on prevention and intervention strategies in Alzheimer's. You'll be treated to the latest on mindfulness and meditation, the default mode network's involvement in Alzheimer's, strategies for assessing and optimizing therapies, stimulation techniques and more. Enjoy! Sections in this e…
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In this episode, Anusha guides you through 11 papers that were published in November of 2022. These papers study the efficacy of treatments targeting neuroprotection in Alzheimer's Disease models. Tune in if you want to be on the cutting edge of drug discovery and development in the field of AD. Sections in this episode: Drug Discovery and Developm…
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Judy is so excited to take you through part 1 of the behavioural and cognitive changes in AD episode (part 2 will be released as a bibliography). This shorter episode features standard motor symptoms like impaired exercise and grip strength, as well as some less studied behavioural changes such as adverse driving in AD. You don’t want to miss this …
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Ellen kicks off the November 2022 series with 11 papers about synaptic transmission and neurotransmitters in Alzheimer's disease. Hear about glutamate, acetylcholine, synaptic proteins, and more in this jam-packed episode! Sections in this episode: Glutamate and Acetylcholine (4:01) GABA neurons (10:52) Neuron Excitability (12:15) Synaptic Proteins…
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Today, we talk all about neuroimaging, with 7 papers that use various imaging modalities in humans, animals, and computational modeling, to study how the brain changes in Alzheimer’s disease. Tune in to learn more! Sections in this episode: Hippocampus (3:50) Hypothalamus (8:15) Cortical regions (10:29) Nucleus basalis (15:57) Pineal gland (18:40) …
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Anusha brings you another episode of AMiNDR featuring literature published in October 2022. In this episode, you'll hear 12 papers that converge on the topic of treatments that target neurotoxicity. This episode is poised to leave you feeling hopeful about the various treatment avenues to be pursued so be sure to tune in! Sections in this episode: …
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In today's episode, there's a big focus on sleep in Alzheimer's disease, as well as other clinical and pharmacological studies that dive into the cognitive and behavioural deficits. We even have one paper that looks into character strengths in AD, so definitely join Judy and follow along in this unique episode from our October 2022 series! Sections…
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In this episode, Elyn takes you through 13 papers from October 2022 published on vascular contributions to Alzheimer disease. It's quite the journey through mechanistic mouse studies, neuroimaging studies, and a few studies assessing treatments targeting the vasculature, which all paint a pretty convincing picture of the importance of the cerebrova…
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Kick off the new year with Ellen, who tells you all about synaptic transmission in Alzheimer's disease in this episode. You'll hear about 5 papers published in October of 2022 on synaptic transmission, ranging from research on whole brain networks all the way down to individual proteins. -------------------------------------------------------------…
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We have one last episode for you to wrap up 2022! In this episode, Naila will guide you through 11 papers published in August 2022, covering a range of way researchers are working on preventing or treating aspects of Alzheimer's disease through non-pharmacological therapies. You'll hear about cognitive training tools, the effects of disrupting circ…
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In this month's episode of AMiNDR, Cassi recaps papers on APOE published in August 2022. Cassi just defended her dissertation where she studied immunometabolism in the context of APOE. She starts with cells, moves to mice, and finishes with human research studies. -------------------------------------------------------------- To find the numbered b…
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Today, we have papers on behavioural and cognitive changes in Alzheimer’s disease. We’ve got our usual sections such as rodent models and sleep, but we also have some new topics, including cognitive reserve and even a paper on virtual reality. You’re in for a treat! Sections in this episode: Behavioural Changes (2:28) Cognitive Changes (11:10) ----…
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After a bit of a break, Elyn is excited to be back with the latest in the field of vascular contributions to Alzheimer disease. With the current (and constant) controversy in the field about targeting amyloid as a disease-modifying therapy, perhaps it's time we turned to a new target: the vasculature. Tune in for an overview of papers published in …
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To kick off our series on August papers, we will talk all about different ways that synaptic transmission may be affected in Alzheimer's disease, with 6 research papers that use either cell models, animal models, or human patients. Stay tuned! Sections in this episode: Cortical signaling in rodent models (3:15) New AD models (8:32) Biomarkers of ne…
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In Part 2 of Cognitive and Behavioural Changes, Naila covers 8 papers on neuropsychiatric, social and cognitive symptoms linked to Alzheimer's disease, and their implications for diagnosis and disease management. You'll learn about the links between AD and depression, the importance of social networks, and machine learning methods for identifying i…
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In this episode, Naila will guide you through 14 papers on potential neuroprotective factors to mitigate the risk of Alzheimer's disease, non-pharmacological interventions that could directly target Alzheimer's pathology, and strategies for symptom management. You'll hear about the role of embodiment in memory, light therapy technologies, the role …
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This is an episode all about targeting synaptic and neuronal heath in Alzheimer's disease. Anusha will cover in silico, in vitro, and in vivo studies of candidate compounds that target neuroprotection and neurogenesis. Be sure to check out this paper to stay up to day on the latest preclinical therapeutics being tested. Sections in this episode: In…
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In this episode exploring the effect of allelic variation of APOE, we review abstracts from large human GWAS studies all the way down to new mouse models expressing the human ApoE proteins. There are some particularly interesting abstracts on protection from cognitive decline despite having a risk allele for Alzheimer's disease. These are great stu…
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Part 1 of our cognitive and behavioural changes category will focus on papers that explore behavioural and sensory processing deficits in AD. Topics range from motor impairments to visual and olfactory processing in both human patients and mouse models of AD. If you're curious about how AD patients process the facial expression of pain, then this i…
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Elyn is back to discuss the latest research on vascular contributions to Alzheimer disease! Tune in to hear about proteomic changes with amyloid deposition in the vasculature, new therapeutic avenues, and a more detailed account of the perivascular space. If you're interested in factors beyond amyloid and tau in the Alzheimer disease pathology, thi…
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We are kicking off our July 2022 series of AMiNDR with this episode and are so glad you are tuning in. If you’re interested in changes to neuronal function in AD, we’ll be covering the entire spectrum in this episode. Starting big with network changes, we scale all the way down to molecular changes that may underlie AD pathology, so if that’s what …
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Today's episode includes 15 papers on non-pharmacological treatments and complementary therapies for AD. Naila will take you through research published in June 2022 on an array of topics including olfactory training, beer, choir participation, light therapy, and transcranial magnetic stimulation. You'll be treated to research on both the human and …
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We promised you we would be back with more on clinical assessment for Alzheimer’s disease, and here we are to deliver. Stick around to hear about papers published in June 2022 on validating variations of the Montreal Cognitive Assessment, tracking Activities of Daily living, and digital tools for assessing cognition. Our harvest yielded 7 abstracts…
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Approximately, one in every five people you know, has a copy of the largest genetic risk allele for late-onset Alzheimer's disease called apolipoprotein E4 (APOE). In this episode, Cassi discusses papers from June 2022 about APOE and covers human subjects research, pathology related to E4 risk, and mechanisms. Sections in this episode: Human Subjec…
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In this episode, Joseph covers papers published in June 2022 on GWAS studies, transcriptomics, genetic and genomic studies and the like on Alzheimer’s disease. Stay tuned! Sections in this episode: Genetic & Disease Overlaps (2:15) RNA & Transcriptomics (5:10) Genetic Testing (10:25) GWAS Studies (15:24) Specific Genes (21:04) Extra (28:55) -------…
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Anusha brings you 12 papers today on the development of treatments that target neuroprotection in Alzheimer's disease. This includes a range of research models, from in silico and drug discovery studies, to rodent models of AD. Enjoy! Sections in this episode: In Silico and Drug Discovery Studies (2:27) Testing Phytochemicals in AD Rodent Models (7…
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This episode contains a whole range of topics in cognitive and behavioural changes in AD! Tune in as Judy covers a variety of papers published in June 2022, spanning from from sensory processing in mouse models to antidepressants in human patients. There's bound to be something that piques your interest! Sections in this episode: Studies Using Mous…
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You are here, with us, right now, about to get the updates you eagerly wait for every month in Alzheimer’s disease research. A whole episode dedicated to assessing neurocognitive domains for screening and diagnostics. Learning and memory? Executive function? Perceptual and motor skills? You got it! 7 abstracts published in June 2022, nicely package…
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Ever thought there was more to Alzheimer disease than the plaques and tangles? You've come to the right place. Join Elyn for a guide through the latest research on vascular contributions to Alzheimer disease. June 2022 brought lots of new insight into how vascular hallmarks interact with the classic AD hallmarks to influence cognition, emphasis on …
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We are kicking off our June 2022 series of episodes with this short and sweet episode. Anusha takes a look at papers published on the subject of changes to synaptic transmission and neuronal excitability in Alzheimer’s disease. If you're interested in bridging the gap between changes to neuronal function and behavioural consequences, this episode i…
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Elyn is back with a short and sweet episode on the latest research on vascular contributions to Alzheimer disease! Tune in for a quick recap of May 2022 research, and a disease perspective a bit more lively than the classic amyloid cascade hypothesis! Clinical Studies (3:53) Preclinical Studies/Methology (12:41) ------------------------------------…
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Anusha is excited to guide you through 12 papers published in May of 2022 that all test different treatment options for Alzheimer’s disease, preclinically. She will cover topics like discovery and development of agents that confer neuronal and synaptic protection or target neuronal function directly. This episode is sure to leave you feeling hopefu…
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