How do pain killers relieve pain?

Chemistry For Your Life

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#195

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In this episode of Chemistry For Your Life, hosts Melissa and Jam delve into the science behind ibuprofen, a common pain reliever. They discuss the role of prostaglandins in inflammation, how ibuprofen inhibits the cox enzyme to reduce pain, and the body's natural immune response. They also share personal anecdotes about meeting listeners, their favorite types of ibuprofen, and explore plans for future episodes about other pain relievers.

00:00 Introduction and Personal Anecdote
01:00 Meet the Hosts
01:11 Exciting Announcements
02:46 Listener Shoutout
05:41 Understanding Pain and Inflammation
06:48 The Role of Prostaglandins
14:38 How Ibuprofen Works
18:15 Personal Experiences with Pain
21:16 Preview of Next Episode
22:10 Understanding Pain and Inflammation
23:07 The Role of Prostaglandins
24:50 Enzymes and Their Functions
27:11 How Ibuprofen Works
35:11 Personal Experiences with Ibuprofen
40:42 Supporting the Show and Final Thoughts

References from this episode:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276492/
https://thispodcastwillkillyou.com/wp-content/uploads/2021/07/TPWKY-Episode-29-Aspirin.pdf
https://www.chemistryworld.com/podcasts/ibuprofen/4011375.article
https://pubs.acs.org/doi/epdf/10.1021/bi010045s?ref=article_openPDF
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355401/ 6. Garret & Grisham Biochemistry Textbook

We want to give a special thanks to Bri McAllister for illustrating molecules for some episodes! Please go check out Bri’s art, follow and support her at entr0pic.artstation.com and @McAllisterBri on twitter!

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