Alexander Disease Research Update - Episode #17: 1) new iPS cell line, 2) acetylation and GFAP, and 3) STAT3 as a key regulator driving GFAP accumulation
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Albee Messing, Rachel Battaglia, and Tracy Hagemann discuss the following recent publications:
[01:45] A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells
Stem Cell Reports 18, 1701-1720 (2023)
[includes new iPS cell line from an individual with Alexander disease] [full text]
[05:39] Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
Journal of Visualized Experiments 18, 55655 (2017)
[includes data on acetylation of lysines in GFAP] [full text]
[10:26] STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease
Cells 12, 978 (2023)
[identification of one of the key mechanisms responsible for the increase in GFAP levels in Alexander disease] [full text]
[22:35] Questions from email: does Alexander disease affect menstrual cycles?
Send your questions and feedback to: axdrupodcast@waisman.wisc.edu
Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:
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