Hematology Series: physiology, diagnostic tools, common coagulation pathology (with Drs. Andrew Jenzer and Maxwell Lloyd)

Everyday Oral Surgery

This conversation kicks off a new series that takes a deep dive into anything blood-related. During this episode, Dr. Andrew Jenzer revisits the podcast alongside Dr. Maxwell Lloyd to demystify some of the key ideas underpinning hemostasis, coagulation, and PTT levels. Join us as we discuss helpful tools to navigate detection, monitoring, testing, and all the factors that may affect results. From PTT and D-Dimer testing to mixed testing options and thrombal elastography, we cover it all. Next, we get into abnormalities and all the elements to consider before going about an invasive surgery of this nation. We get into detail about Von Willebrand’s disease and what testing can tell you, after considering why clinical history is specifically important for the treatment of bleeding issues. Lastly, we discuss OMS-specific hemostatic agents, and the impact of CRASH 1, 2, and 3 trials on how we implement TXA. Join us today to hear all this and more.

Key Points From This Episode:

• Introducing Drs. Andrew Jenzer and Maxwell Lloyd.
• Dr. Jenzer’s upcoming mock boards course for residents.
• The topic of this episode which kicks off a new series: blood and anything blood related.
• Differentiating between primary and secondary hemostasis.
• Understanding intrinsic and extrinsic pathways.
• Why all coagulation factors are ultimately made in the liver.
• The importance of interpreting the lab values.
• Using the WETT acronym in the context of anti-coagulation.
• Monitoring through PTT.
• D-Dimer testing and why it is so often misunderstood.
• What is essential to do when mixing tests together.
• Another test option: thrombal elastography.
• Thinking about the risks and benefits of stopping anticoagulation.
• Developing a schema to think about abnormalities.
• Understanding how to address Haemophilia A and B.
• Why clinical history is particularly important for bleeding issues.
• Demystifying Von Willebrand’s disease and what testing can tell you.
• OMS-specific hemostatic agents, which ones work best, and more.
• CRASH 1, 2 and 3 trials and TXA.

Links Mentioned in Today’s Episode:

Dr. Maxwell Lloyd on Google Scholar — https://scholar.google.com/citations?user=D0agka0AAAAJ
Dr. Andrew Jenzer Email — [e-mail]
Dr. Andrew Jenzer — https://surgery.duke.edu/profile/andrew-clark-jenzer
CRASH-1 — https://pmc.ncbi.nlm.nih.gov/articles/PMC33506/
CRASH-2 — https://pmc.ncbi.nlm.nih.gov/articles/PMC4576020/
CRASH-3 — https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32233-0/fulltext
Everyday Oral Surgery Website — https://www.everydayoralsurgery.com/
Everyday Oral Surgery on Instagram — https://www.instagram.com/everydayoralsurgery/
Everyday Oral Surgery on Facebook — https://www.facebook.com/EverydayOralSurgery/
Dr. Grant Stucki Email — [e-mail]
Dr. Grant Stucki Phone — 720-441-6059