Natural Compounds That Use Iron To Kill Cancer

The Alpha Human Podcast

Disclaimer: The content of this podcast, and any information, advice, opinions or statements within it are not intended, and are not to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not disregard or delay in obtaining medical advice for any medical condition you may have, and you should seek the assistance of a healthcare professional for any such conditions, and always inform your doctor of any changes you make, or are thinking about making to your lifestyle. In this episode of The Alpha Human Podcast, Lawrence delves into the science behind several natural compounds that hold the power to combat cancer by triggering ferroptosis. These include: Withaferin-A, isolated from the roots of Withania Somnifera (Ashwagandha), a traditional medicinal plant that has been found to induce ferroptosis and be significantly more potent than the standard chemotherapeutics Etoposide and Cisplatin in killing a set of high-risk neuroblastoma cell lines: Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma jci.org/articles/view/99032 Withania somnifera: from prevention to treatment of cancer ncbi.nlm.nih.gov/pmc/articles/PMC4899165/ Berberine, a natural compound that appears to exhibit selective effects on ferroptosis (protecting healthy cells from the deadly effects of iron-mediated ROS while using these very same free radicals to induce cell death in cancer cells): Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway spandidos-publications.com/10.3892/or.2021.8204 Berberine inhibits erastin-induced ferroptosis of mouse hippocampal neuronal cells possibly by activating the Nrf2-HO-1/GPX4 pathway pubmed.ncbi.nlm.nih.gov/35790446/ Berberine Induces Combined Cell Death in Gastrointestinal Cell Lines mdpi.com/1422-0067/24/7/6588 Quercetin, a flavonoid that has been linked to the inhibition of multiple cancer types through various mechanisms also promotes ferroptosis via lysosomal activation: Quercetin induces p53-independent cancer cell death through lysosome activation by the transcription factor EB and Reactive Oxygen Species-dependent ferroptosis bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15350 Plumbago Zeylanica, known as Ceylon Leadwort, which demonstrates anticancer activity against multiple cancer cell lines through diverse mechanisms, has also been shown to induce ferroptosis in glioma cells: Anticancer Effects and Mechanisms of Action of Plumbagin: Review of Research Advances ncbi.nlm.nih.gov/pmc/articles/PMC7725562/ Targeting NQO1/GPX4-mediated ferroptosis by plumbagin suppresses in vitro and in vivo glioma growth nature.com/articles/s41416-022-01800-y Piperlongumine, an alkaloid extracted from the fruits and roots of Piper longum Linn, which exhibits anxiolytic, antiangiogenic, anti-metastatic, anti-tumoral, cytotoxic activity has also been found to induce Ferroptosis in pancreatic cancer cells: The promising potential of piperlongumine as an emerging therapeutics for cancer ncbi.nlm.nih.gov/pmc/articles/PMC9400693/ Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent sciencedirect.com/science/article/abs/pii/S1043661820307830?via%3Dihub Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis spandidos-publications.com/10.3892/ijo.2018.4259 Curcumin, a natural compound found in turmeric, has been shown to induce ferroptosis in breast cancer cells and non-small-cell lung cancer cells: Curcumin suppresses tumorigenesis by ferroptosis in breast cancer bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15350 Curcumin induces ferroptosis in non-small-cell lung cancer via activating autophagy onlinelibrary.wiley.com/doi/10.1111/1759-7714.13904