Going Anti-Viral podcast

#Fitness #Medicine #Going AntiViral

44:09

When a young Eva Kollisch arrives as a refugee in New York in 1940, she finds a community among socialists who share her values and idealism. She soon discovers ‘the cause’ isn’t as idyllic as it seems. Little does she know this is the beginning of a lifelong commitment to activism and her determination to create radical change in ways that include belonging, love and one's full self. In addition to Eva Kollisch’s memoirs Girl in Movement (2000) and The Ground Under My Feet (2014), LBI’s collections include an oral history interview with Eva conducted in 2014 and the papers of Eva’s mother, poet Margarete Kolllisch, which document Eva’s childhood experience on the Kindertransport. Learn more at www.lbi.org/kollisch . Exile is a production of the Leo Baeck Institute , New York | Berlin and Antica Productions . It’s narrated by Mandy Patinkin. Executive Producers include Katrina Onstad, Stuart Coxe, and Bernie Blum. Senior Producer is Debbie Pacheco. Associate Producers are Hailey Choi and Emily Morantz. Research and translation by Isabella Kempf. Sound design and audio mix by Philip Wilson, with help from Cameron McIver. Theme music by Oliver Wickham. Voice acting by Natalia Bushnik. Special thanks to the Kollisch family for the use of Eva’s two memoirs, “Girl in Movement” and “The Ground Under My Feet”, the Sophia Smith Collection at Smith College and their “Voices of Feminism Oral History Project”, and Soundtrack New York.…

Going anti-Viral

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Introducing Going anti-Viral, the podcast of the IAS–USA, a professional continuing medical education organization focused on HIV and other viral diseases. I’m Dr Michael Saag, professor emeritus of medicine and infectious diseases at the University of Alabama at Birmingham and volunteer member of the IAS–USA Board of Directors.
Join us as we interview experts in viral medicine about their area of specialty and current developments in the field. Other episodes are drawn from the IAS-USA vast catalogue of panel discussions, Dialogues, and various meetings and conferences.
Going anti-Viral is a podcast series for clinicians, produced by the International Antiviral Society–USA. The IAS–USA is a not-for-profit professional organization committed to improving the treatment, care, and quality of life for people with or at risk for HIV or other viral infections and their complications through balanced education and information. This podcast is intended as a technical source of information for specialists in this field, but we hope anyone listening will enjoy learning more about the state of modern medicine around viral infections and their consequences.

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Going anti-Viral

updated 1天之前

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#Fitness #Medicine #Going AntiViral

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Going anti-Viral

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Episode 40 – HIV Cure Research: State of the Art and Navigating Presentations at CROI 2025 27:31

1 day之前27:31

27:31

In this episode of Going anti -Viral, Dr Michael Saag speaks with Dr Joseph Eron, Professor of Medicine at University of North Carolina (UNC) about the topic of his upcoming presentation at the Conference on Retroviruses and Opportunistic Infections (CROI) 2025: HIV Cure Research: State of the Art and Navigating Presentations at CROI 2025 . Dr Eron discusses the state of HIV cure research including a detailed discussion of why it has been so difficult to develop a cure for HIV. Dr Saag and Dr Eron discuss the difference between HIV cure and functional cure and provide a detailed overview of cure research efforts looking at blocking and locking HIV in human DNA. Dr Saag and Dr Eron also discuss the potential for “molecular scissors” (CRISPR-Cas9) to cure HIV. Finally, they provide an overview of cure research that will be presented at CROI, highlighting the plenary presentation by Dr Ole Søgaard at CROI on Monday March 10 entitled HIV Cure: A Translational Research Perspective. For more information about the topic of this episode, listen to an earlier episode of Going anti -Viral where Dr Saag discusses Vaccine Development with Dr Richard Koup, see links in the resources below. 0:00 – Introduction 1:31 – Defining cure in the context of HIV 4:56 – Why is it so hard to cure HIV 7:56 – What is functional cure 11:47 – Description of the concept of “block and lock” in human DNA 14:33 – Discussion of tat inhibitors – blocking of HIV regulatory genes 18:02 – Prospect of using “molecular scissors” (CRISPR-Cas9) as a cure 23:13 – Highlights in HIV cure research at CROI and closing remarks Resources : CROI 2025: https://www.croiconference.org/ Going anti-Viral Episode 4 – A Deep Dive into Vaccine Development with Dr Richard Koup: Apple Podcasts: https://podcasts.apple.com/us/podcast/episode-4-a-deep-dive-into-vaccine-development-with/id1713226144?i=1000637677124 YouTube: https://youtu.be/nXeMt3GMj4Q __________________________________________________ Produced by IAS-USA, Going anti –Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti- Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode. Follow Going anti-Viral on: Apple Podcasts YouTube X Facebook Instagram ...…

Going anti-Viral

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Episode 39 - Preview of the 2025 Conference on Retroviruses and Opportunistic Infections (CROI) 26:04

9天之前26:04

26:04

In this episode of Going anti -Viral, Dr Michael Saag speaks with Dr Diane Havlir, Professor of Medicine at the University of California San Francisco. Dr Havlir currently serves as Chair of the Scientific Program Committee for the 2025 Conference on Retroviruses and Opportunistic Infections (CROI) and joins Dr Saag to provide a preview of CROI 2025. Dr Havlir provides an overview and history of CROI along with a summary of how the program is developed. Dr Saag and Dr Havlir review why CROI is unique among scientific meetings: leading scientific advances, poster sessions, and the focus on supporting new investigators. They also discuss expected hot topics from CROI such as: HIV treatment and cure, STI prevention, weight management, aging and HIV, as well as pediatric and adolescent care. Dr Saag and Dr Havlir provide an overview of resources that will be available to those who will not attend CROI in person. Finally, they discuss the value of CROI during a challenging time for all involved in the field of HIV research, care, and treatment. 0:00 – Introduction 1:36 – Overview and history of CROI 4:12 – What makes CROI unique 6:21 – Discussion of how the CROI program is developed both abstract and invited presentations 11:04 – How attendees can interact at CROI 12:06 – Features of poster abstract sessions and poster hall 13:42 – CROI focus on new investigators 17:55 – Hot topics at CROI 2025 20:45 – Resources for people not attending CROI 22:26 – Value of CROI during a challenging time and closing remarks CROI Resources : https://www.croiconference.org/ __________________________________________________ Produced by IAS-USA, Going anti –Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti- Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode. Follow Going anti-Viral on: Apple Podcasts YouTube X Facebook Instagram ...…

Going anti-Viral

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Episode 38 - Update on COVID-19 with Dr Andy Pavia 31:36

26天之前31:36

31:36

In this episode of Going anti -Viral, Dr Michael Saag speaks with Dr Andy Pavia of the University of Utah for an update on COVID-19. Dr Pavia and Dr Saag review COVID-19 cases and deaths in 2024 including a discussion about the reasons why deaths have declined compared with earlier years in the pandemic. They also review Long COVID and challenges clinicians face with treatment. Dr Pavia provides a detailed review of COVID-19 vaccines and effectiveness including recommendations on who should be vaccinated. Dr Saag and Dr Pavia review COVID-19 testing, including home testing and antiviral (including monoclonal antibody) treatments. They also discuss how best to provide early treatment to persons at high risk of developing severe disease. Finally, they provide predictions for the future including possible improvements in next generation of COVID-19 vaccines. 0:00 – Introduction 1:21 – COVID-19 cases and deaths in 2024 3:21 – Discussion of reduction in deaths 5:11 – Evolution of COVID-19 immunity and discussion of Long COVID 12:37 – Challenges in treating Long COVID 16:20 – Review of data on effectiveness of COVID-19 vaccines and current recommendations on who should receive a vaccine 19:10 – Recommendations on use of antiviral treatments and testing – including recommendations for persons at high risk for developing severe disease 23:16 – Discussion of use of remdesivir 24:44 – Recommendations for use of pemivibart in persons who are immune compromised 26:30 – Predictions for future therapies and vaccines 28:11 – Summary and closing remarks __________________________________________________ Produced by IAS-USA, Going anti –Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti- Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode. Follow Going anti-Viral on: Apple Podcasts YouTube X Facebook Instagram ...…

Going anti-Viral

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Episode 37 - What’s New in Primary Care of HIV 30:52

6 weeks之前30:52

30:52

In this episode of Going anti -Viral, Dr Michael Saag speaks with Dr Melanie Thompson who is a clinical researcher and provider of HIV clinical care in Atlanta, Georgia. As Principal Investigator and Executive Director of the AIDS Research Consortium of Atlanta (ARCA), she has led over 400 studies of HIV treatment and prevention and is recognized as an expert in the treatment of patients with HIV. In the episode, Dr Thompson and Dr Saag discuss the recently released 2024 update of primary care guidance for providers who care for persons with HIV by the HIV Medicine Association of the Infectious Diseases Society of America (see links in resources below). They address topics such as telemedicine, outreach to underserved populations, and how to create a welcoming clinic to improve retention in care. They discuss how HIV providers have been leaders in primary care in areas like hepatitis and address how to bring future generations of providers into HIV medicine. Finally, they address the importance of providers being advocates to their elected representatives about HIV medicine and that providing care to individuals, no matter who they are and where they come from, improves overall public health. 0:00 – Introduction 1:30 – A discussion of Dr Thompson’s background in HIV medicine and transition from primary care to focus on HIV 4:54 – What’s new in the recently released primary care guidelines for persons with HIV 8:40 – Discussion of new recommendations in how providers can manage outreach, including providing mobile care to individuals with substance use disorder and unstable housing 15:15 – Treatment of hepatitis as an example of how HIV medicine has led the way in providing primary care 17:04 – Review of guidance on substance use disorder including the use of Narcan and Buprenorphine 19:14 – Reflections on the importance of providers being advocates to their elected representatives 24:10 – A discussion of how to create a future generation of HIV providers whether from internal medicine or infectious diseases, or both 28:05 – Closing remarks Resources HIV Medicine Association - https://www.hivma.org/ HIVMA/IDSA HIV Primary Care Guidance - https://academic.oup.com/cid/advance-arti __________________________________________________ Produced by IAS-USA, Going anti –Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti- Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode. Follow Going anti-Viral on: Apple Podcasts YouTube X Facebook Instagram ...…

Going anti-Viral

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Must Listen Episode - Latest Update on Emerging Viral Infections and Current Public Health Threats 1:03:33

7 weeks之前1:03:33

1:03:33

This episode of Going anti -Viral features an IAS–USA Dialogue titled "Latest Update on Urgent Viral Outbreaks," a panel discussion held on January 15, 2025. This IAS-USA Dialogue is a must listen as our distinguished panel of infectious diseases experts dives deep into some of the most pressing public health challenges facing the world today. Moderated by Carlos del Rio, MD, a Distinguished Professor of Medicine in the Division of Infectious Diseases at Emory University School of Medicine, this Dialogue brings together world-class experts Yvonne Maldonado, MD, Peter Chin-Hong, MD, and Jason Zucker, MD, to discuss the latest news on urgent and emerging viral outbreaks, including mpox, avian flu (H5N1), respiratory syncytial virus (RSV), measles, human metapneumovirus, and COVID-19/long COVID. The panel also reflects on the alarming erosion of public trust in public health experts, which has been compounded by misinformation and the long-term effects of the COVID-19 pandemic. 0:00 – Introduction 2:27 – Update on mpox including treatment options 11:09 – Discussion of avian flu (H5N1), influenza, and vaccination in human and animals 27:36 – Impact of avian flu (H5N1) on dairy and other agriculture industries and the role of public health in supporting the economy 32:47 – Impact of recent study on Tamiflu in treatment recommendations and discussion of Biloxivir 37:37 – Update on COVID-19 – vaccination, treatment with Paxlovid, other treatment options, and long COVID 48:27 – Recent updates on respiratory syncytial virus (RSV) and vaccination 52:03 – Discussion of human metapneumovirus 54:25 –Impact of misinformation on the reduction in measles vaccinations and the health risks of measles to the population at large 59:54 – Concluding remarks __________________________________________________ Produced by IAS-USA, Going anti –Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti- Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode. Follow Going anti-Viral on: Apple Podcasts YouTube X Facebook Instagram ...…

Going anti-Viral

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Episode 35 - Reflections on the Role of HRSA in the Care of People with HIV – Laura Cheever 32:48

8 weeks之前32:48

32:48

In this episode of Going anti -Viral, Dr Michael Saag speaks with Dr Laura Cheever who was, until recently, the Associate Administrator of the HIV/AIDS Bureau at the Health Resources and Services Administration (HRSA). She joined HRSA in 1999 when she served as the national director of the Ryan White AIDS Education and Training Center program. Dr Cheever is Board Certified in Infectious Diseases and continues to provide clinical care for patients with HIV. Dr Cheever describes her early work at HRSA and the Ryan White HIV/AIDS Program. Dr Cheever and Dr Saag then discuss quality measures adopted to demonstrate program effectiveness and the impact these efforts had on funding. They also discuss the staff in the program and their role in working with local providers. They address the role that private insurance, the Affordable Care Act, and different presidential administrations play in the services of the program as well as work left to be done and look ahead to the next ten years of HIV care. 0:00 – Introduction 1:40 – A discussion of Dr Cheever’s early years at the Health Resources and Services Administration (HRSA) 7:51 – Implementation of national quality measures for HIV care using data collection through CAREWare 11:41 – How did new information impact decision making regarding Ryan White funding decisions 15:04 – Impact of changing guidelines on direction given to the Ryan White clinics 19:26 – The staff at HRSA and the impact of potential budget cuts on the program 24:05 – The role private insurance and the Affordable Care Act had in providing treatment through the Ryan White program 25:10 – Do different presidential administrations influence the services of the Ryan White program 27:34 – Discussion of the work left to be done 29:29 – Predictions for the next ten years of HIV care and closing remarks __________________________________________________ Produced by IAS-USA, Going anti –Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti- Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode. Follow Going anti-Viral on: Apple Podcasts YouTube X Facebook Instagram ...…

Going anti-Viral

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Episode 34 – How far we’ve come with HIV – J. Kevin Carmichael 35:34

10 weeks之前35:34

35:34

In this episode of Going anti -Viral, Dr Michael Saag speaks with Dr Kevin Carmichael of the Arizona Department of Health Services about the unique challenges caregivers faced in addressing the HIV/AIDS pandemic. Dr Carmichael is a family physician who began work in HIV in 1983 while in medical school in Miami, Florida. During his residency at the University of Miami, Dr Carmichael co-authored one of the first written guidance for clinical HIV care “HIV/AIDS: A Primary Care Handbook.” Dr Saag and Dr Carmichael discuss their shared history in caring for people during the early years of HIV and AIDS in the 1980s and 1990s. They also discuss the challenges in managing families of people with AIDS. Dr Carmichael then reflects upon the transition in the care of HIV in 1995 when protease inhibitors became available, effectively the start of turning HIV into a manageable chronic disease. Finally, Dr Saag and Dr Carmichael provide thoughts for younger practitioners currently involved in HIV management. 0:00 – Introduction 1:22 – A discussion of the early years of HIV and AIDS care in the 1980s 7:43 – How Dr Carmichael came to focus on HIV and AIDS care 12:36 – Dr Carmichael’s transition to care in Arizona and differences from his time in Miami 16:08 –Discussion of advanced AIDS and working with families of people with HIV at the time 23:12 – The arrival of protease inhibitors in 1995 and the transition to management of a chronic disease 31:00 – Closing remarks and reflections for younger practitioners involved in HIV care __________________________________________________ Produced by IAS-USA, Going anti –Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti- Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode. Follow Going anti-Viral on: Apple Podcasts YouTube X Facebook Instagram ...…

Going anti-Viral

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Episode 33 - Overview of Travel Medicine: Vaccines, Outbreaks, and More - Dr David Freedman 34:17

12 weeks之前34:17

34:17

Episode 33 - Overview of Travel Medicine: Vaccines, Outbreaks, and More - Dr David Freedman In this episode of Going anti -Viral, Dr Michael Saag speaks with Dr David Freedman of the University of Alabama at Birmingham to provide an overview of travel medicine: vaccines, outbreaks, and more. Dr Freedman is a professor of infectious diseases and his research is focused on clinical tropical medicine, including the development of surveillance networks to characterize infectious disease morbidity in travelers and migrants. Dr Saag and Dr Freedman provide an overview of worldwide outbreaks such as: mpox, H5N1, Marburg virus, Ebola, dengue fever, chikungunya, and Zika virus. Dr Freedman discusses the treatments and vaccines available for each of these outbreaks. They also address the clinical challenges of treating individuals with emerging infections of unknown origin. Finally, Dr Saag and Dr Freedman address the acute setting of treating rabies exposures from bats and other wild animals. 0:00 – Introduction 1:11 – Overview of surveillance networks and current areas of concern 4:01– Discussion of mpox outbreaks including a new clade in the Democratic Republic of the Congo 7:10 – Risk of H5N1 human transmission 10:07 – Update on Marburg virus disease 12:22 – Current status of Ebola disease and availability of monoclonal antibodies for treatment 15:53 – Overview of outbreaks in the Caribbean: dengue fever and chikungunya 25:08 – Update on Zika virus 26:36 – Discussion of how to clinically address cases of emerging viruses like Oropouche virus 29:50 – How to prevent and treat rabies exposures from bats and other animals __________________________________________________ Produced by IAS-USA, Going anti –Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti- Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode. Follow Going anti-Viral on: Apple Podcasts YouTube X Facebook Instagram ...…

Going anti-Viral

1
Episode 32 - Update on the New Antiretroviral Therapy Guidelines - Dr Rajesh Gandhi 36:25

14 weeks之前36:25

36:25

In this episode of Going anti -Viral, Dr Michael Saag speaks with Dr Rajesh Gandhi of Harvard Medical School and Massachusetts General Hospital about the new IAS-USA recommendations for HIV treatment and prevention. Dr Gandhi is the Chair of the guidelines panel, which published its recommendations in the Journal of the American Medical Association on December 1, 2024. Dr Gandhi and Dr Saag discuss the process by which the updated guidelines were created and provide an update on what’s new in the current edition. They address other important topics like how to treat patients with opportunistic infections, guidance on when to change therapy, and strategies for preventing HIV acquisition. Finally, Dr Gandhi makes recommendations for those using the guidelines, especially those using them for the first time. 0:00 – Introduction 1:19 – Overview of the guidelines’ creation process 3:52– New recommendations on when to start antiretroviral therapy 6:37 – New guidance on what regimens to start 9:34 – Discussion of other agents like bictegravir and dolutegravir in pregnancy 10:45 – How to treat patients with an opportunistic infection 14:09 – Concern about immune reconstitution inflammatory syndrome (IRIS) 16:33 – Guidance on when to change therapy and providing support 21:18 – How do the guidelines help people stay healthy – management of cancer, cardiovascular risk, and weight gain 24:41 – Discussion on prevention of HIV and sexually transmitted diseases 30:19 – What could not be addressed in the guidelines 33:17 – Final comments and how to use the guidelines Resources: https://jamanetwork.com/ __________________________________________________ Produced by IAS-USA, Going anti –Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti- Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode. Follow Going anti-Viral on: Apple Podcasts YouTube X Facebook Instagram ...…

Going anti-Viral

1
Episode 31 - Will we ever have a cure for Hepatitis B? - Dr Kenneth Sherman 31:25

16 weeks之前31:25

31:25

In this episode of Going anti -Viral, Dr Michael Saag speaks with Dr Kenneth Sherman of Massachusetts General Hospital and Harvard Medical School about the possibility of a cure for hepatitis B. The World Health Organization estimates that 254 million people were living with chronic hepatitis B globally in 2022. Dr Saag and Dr Sherman discuss the lifecycle of hepatitis B including the role that covalently closed circular DNA (cccDNA) plays in the hepatitis B virus (HBV) replication cycle. Dr Sherman defines functional cure and provides an overview of the most promising cure strategies. They also discuss whether antiretroviral drugs like tenofovir, used in the treatment of HIV, can contribute toward a functional cure of hepatitis B. Dr Sherman discusses other strategies like capsid assembly modulators (CAMs), monoclonal antibodies, and toll-like receptor (TLR) agonists. Finally, they discuss the effectiveness of the hepatitis B vaccine in prevention and look forward to the future by considering a timeline for a cure based on the status of ongoing clinical trials. 0:00 – Introduction 1:23 – Overview of the lifecycle of hepatitis B 5:29 – Discussion of the most promising cure strategies 7:11 – Defining functional cure 10:56 – The role of drugs like tenofovir in a functional cure 13:39 – Targets that can affect viral production 16:04 – Potential of capsid assembly modulators (CAMs) 18:03 – Other strategies like immune modulators and monoclonal antibodies 22:29 – Interest in toll-like receptor (TLR) agonists and therapeutic vaccines 24:32 – Outlook for the future and the effectiveness of a hepatitis B vaccine in prevention __________________________________________________ Produced by IAS-USA, Going anti –Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti- Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode. Follow Going anti-Viral on: Apple Podcasts YouTube X Facebook Instagram ...…

Going anti-Viral

1
Episode 30 - Update on Mpox - a Public Health Emergency - Dr Jason Zucker 23:31

18 weeks之前23:31

23:31

In this episode of Going anti -Viral, Dr Michael Saag speaks with Dr Jason Zucker of Columbia University and the New York City STD Prevention Training Center about mpox and the mpox outbreak. Dr Saag and Dr Zucker discuss the 2 clades of mpox, how it is transmitted, and which clade is associated with the most recent mpox outbreak. They also discuss how to test for mpox and how people with HIV present with mpox based on their HIV viral load. Dr Zucker gives a detailed update on the STOMP (Study of Tecovirimat for Human Mpox Virus) trial that evaluates the efficacy of the antiviral tecovirimat, also known as TPOXX, for the treatment of mpox. They also address the role of vaccination in mpox, its uptake and efficacy. Finally, Dr Zucker offers his perspective on how practitioners and public health officials can address ongoing mpox outbreaks in the US and globally, including a second public health emergency of international concern that was declared in the Democratic Republic of the Congo and surrounding countries in August by the World Health Organization (WHO). 0:00 – Introduction 1:25 – Description of mpox and its 2 clades 2:07 – Overview of the current mpox outbreak 3:11 – Mpox transmission 4:29 – Mpox in people with HIV 6:35 – Testing for mpox 9:05 – The STOMP study, enrollment, and effectiveness of tecovirimat 15:58 – The role for vaccination for mpox and who should receive it 20:38 – Outlook for the future __________________________________________________ Produced by IAS-USA, Going anti –Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti- Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode. Follow Going anti-Viral on: Apple Podcasts YouTube X Facebook Instagram ...…

Going anti-Viral

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Episode 29 - Comparing and Contrasting Health Care Policies from different sides of the Aisle - Dr Jennifer Kates 28:53

20 weeks之前28:53

28:53

In this episode of Going anti -Viral, Dr Michael Saag speaks with Dr Jennifer Kates of KFF to compare and contrast health care policies from different sides of the aisle. Dr Kates provides an update on the Patient Protection and Affordable Care Act (ACA) and efforts to repeal the healthcare program in the United States. Dr Saag and Dr Kates also discuss the status of Medicaid expansion in the US and the impact of access to care in states where Medicaid has been expanded. They also discuss the impact of the Ryan White HIV/AIDS Program on healthcare for people with HIV and the long-term outlook for funding for the program. In addition, there is a detailed overview and outlook of funding for the 340B Drug Pricing Program that allows eligible hospitals and other healthcare organizations to purchase outpatient drugs at a discount from pharmaceutical manufacturers. Finally, Dr Saag and Dr Kates discuss the erosion of trust in science and public health officials in the US and reasons to be optimistic for the future. 0:00 – Introduction 1:15 – Update on the ACA 3:19 – Discussion of efforts to repeal the ACA 5:32 – Status of Medicaid expansion in the US 8:56 – Overview of access to HIV care through Ryan White 10:37 – Access to health insurance coverage through Ryan White 12:31 – What is 340B funding? 15:45 – Possible pressures on 340B funding 17:45 – Outlook for Ryan White funding and availability of PrEP in the program 21:34 – Discussion of the erosion of trust in science and public health 26:42 – Outlook for the future __________________________________________________ Produced by IAS-USA, Going anti –Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti- Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode. Follow Going anti-Viral on: Apple Podcasts YouTube X Facebook Instagram ...…

Going anti-Viral

1
Episode 28: Special Episode - Latest Update on Urgent Virus Outbreaks: October 2024 1:02:12

21 weeks之前1:02:12

1:02:12

This episode of Going anti -Viral features an IAS–USA Dialogue titled "Latest Update on Urgent Viral Outbreaks," a panel discussion held on October 4, 2024. Dr Carlos del Rio from Emory University serves as moderator and welcomes 3 distinguished panelists: Dr Yvonne Maldonado from Stanford University, Dr Peter Chin-Hong from the University of California San Francisco, and Dr Paul Sax from Brigham and Women’s Hospital. The episode covers various pressing topics, including updates on COVID-19, avian flu, mpox, and other viral diseases. Discussions touch on vaccines, their effectiveness, public health approaches, and current research. 0:00 – Introduction and overview of ongoing viral outbreaks 3:59 – Update on respiratory viruses and vaccination – seasonal flu, RSV, and COVID-19 12:17 – Discussion of monoclonal antibody treatment for COVID-19 14:15 – Update on the use of Paxlovid for COVID-19 18:48 – COVID-19 vaccination – protein vaccines vs. mRNA vaccines 22:48 – Update on pertussis 28:54 – Discussion of seasonal influenza and vaccination 32:55 – Effectiveness of shingles and RSV vaccines 35:57 – Discussion of vaccination during pregnancy 40:02 – Audience questions 43:04 – Update on H5N1 (avian flu) outbreak 52:00 – Update on Marburg virus outbreak in Rwanda 55:43 – Discussion of mpox outbreak in central Africa 59:29 – Concluding remarks __________________________________________________ Produced by IAS-USA, Going anti –Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti- Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode. Follow Going anti-Viral on: Apple Podcasts YouTube X Facebook Instagram ...…

Going anti-Viral

1
Episode 27 - What’s Hot from the Warm Line: Top 10 Questions from HIV Clinicians 32:22

22 weeks之前32:22

32:22

In this episode of Going anti -Viral, Dr Michael Saag speaks with Dr Carolyn Chu and Dr Lealah Pollock from the University of California San Francisco about the National Clinician Consultation Center (NCCC). The NCCC offers guidance to health care practitioners on HIV, hepatitis, and substance use. Dr Chu and Dr Pollock discuss the most common questions asked by clinicians to the NCCC warm line such as: infant feeding by people with HIV, antiretroviral treatment (ART) for pregnant people with HIV, and the use of long-acting antiretroviral drugs. They also discuss how they respond to questions about the latest developments in preexposure prophylaxis (PrEP) care, care for people with sexually transmitted infections (STIs), and health care practitioner exposures. Finally, they share their thoughts about working for the NCCC and the service they offer to US-based clinicians. 0:00 – Introduction 1:31 – History and overview of the services provided by the NCCC 4:31 – A common question – infant feeding in people with HIV 10:03 – ART for pregnant people with HIV 13:53 – Questions about long-acting antiretroviral drugs 16:55 – Interpretation of resistance-associated mutations 18:30 – The NCCC warm line service model 20:34 – Questions about administering PrEP and impact of recent developments in PrEP research 26:08 – Questions about postexposure prophylaxis (PEP) for STIs 27:25 – Recommendations for health care practitioner exposures 29:17 – Final thoughts and closing remarks Resources: Contact the National Clinician Consultation Center (NCCC): https://nccc.ucsf.edu/ __________________________________________________ Produced by IAS-USA, Going anti –Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections. Going anti- Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode. Follow Going anti-Viral on: Apple Podcasts YouTube X Facebook Instagram ...…

Going anti-Viral

1
Episode 26 - The Exploding Epidemic of Substance Use Disorder: What Can We Do? - Dr Sandra Springer 28:21

24 weeks之前28:21