Science Friction has a new series: Cooked. We dig into food science pickles. Why are studies showing that ice cream could be good for you? Do we really need as many electrolytes as the internet says? And why are people feeling good on the carnivore diet? Nutrition and food scientist Dr Emma Beckett takes us through what the evidence says about food categories and ingredients like meat, dairy and salt — and unpick why nutrition studies can be so conflicting and confusing. Airs Wednesday 11:30 ...
…
continue reading
内容由Sean P. Kane, PharmD, BCPS, Sean P. Kane, and PharmD; Khyati Patel提供。所有播客内容（包括剧集、图形和播客描述）均由 Sean P. Kane, PharmD, BCPS, Sean P. Kane, and PharmD; Khyati Patel 或其播客平台合作伙伴直接上传和提供。如果您认为有人在未经您许可的情况下使用您的受版权保护的作品，您可以按照此处概述的流程进行操作https://zh.player.fm/legal。
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172 - Battle of the Clot Busters: Alteplase vs. Tenecteplase for Acute Ischemic Stroke
Manage episode 379345736 series 2391262
内容由Sean P. Kane, PharmD, BCPS, Sean P. Kane, and PharmD; Khyati Patel提供。所有播客内容（包括剧集、图形和播客描述）均由 Sean P. Kane, PharmD, BCPS, Sean P. Kane, and PharmD; Khyati Patel 或其播客平台合作伙伴直接上传和提供。如果您认为有人在未经您许可的情况下使用您的受版权保护的作品，您可以按照此处概述的流程进行操作https://zh.player.fm/legal。
In this episode, we review the role and indications of thrombolytics in acute ischemic stroke. The efficacy, safety, administration considerations, and cost between alteplase and tenecteplase are compared and contrasted.
Key Concepts
- Alteplase (Activase) is a recombinant DNA version of human TPA (tissue plasminogen activator). Tenecteplase (TNKase) is similar to human TPA except it has three amino acid changes that result in a longer half-life and higher fibrin specificity.
- In patients with stroke, alteplase is given as a bolus followed by a 60-minute infusion. Tenecteplase is given as an IV bolus without the need for an infusion due to its longer half-life.
- Tenecteplase is at least as safe and effective as alteplase in acute ischemic stroke (with some studies showing greater benefit with tenecteplase).
- In patients with acute ischemic stroke who are candidates for mechanical thrombectomy, thrombolytics (with alteplase or tenecteplase) will still be given in patients who meet inclusion criteria and have no exclusion criteria.
References
- Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association [published correction appears in Stroke. 2019 Dec;50(12):e440-e441]. Stroke. 2019;50(12):e344-e418. doi:10.1161/STR.0000000000000211
- Campbell BCV, Mitchell PJ, Churilov L, et al. Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke. N Engl J Med. 2018;378(17):1573-1582. doi:10.1056/NEJMoa1716405
- Kobeissi H, Ghozy S, Turfe B, et al. Tenecteplase vs. alteplase for treatment of acute ischemic stroke: A systematic review and meta-analysis of randomized trials. Front Neurol. 2023;14:1102463. Published 2023 Jan 23. doi:10.3389/fneur.2023.1102463
201集单集
172 - Battle of the Clot Busters: Alteplase vs. Tenecteplase for Acute Ischemic Stroke
HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast
分享
Manage episode 379345736 series 2391262
内容由Sean P. Kane, PharmD, BCPS, Sean P. Kane, and PharmD; Khyati Patel提供。所有播客内容（包括剧集、图形和播客描述）均由 Sean P. Kane, PharmD, BCPS, Sean P. Kane, and PharmD; Khyati Patel 或其播客平台合作伙伴直接上传和提供。如果您认为有人在未经您许可的情况下使用您的受版权保护的作品，您可以按照此处概述的流程进行操作https://zh.player.fm/legal。
In this episode, we review the role and indications of thrombolytics in acute ischemic stroke. The efficacy, safety, administration considerations, and cost between alteplase and tenecteplase are compared and contrasted.
Key Concepts
- Alteplase (Activase) is a recombinant DNA version of human TPA (tissue plasminogen activator). Tenecteplase (TNKase) is similar to human TPA except it has three amino acid changes that result in a longer half-life and higher fibrin specificity.
- In patients with stroke, alteplase is given as a bolus followed by a 60-minute infusion. Tenecteplase is given as an IV bolus without the need for an infusion due to its longer half-life.
- Tenecteplase is at least as safe and effective as alteplase in acute ischemic stroke (with some studies showing greater benefit with tenecteplase).
- In patients with acute ischemic stroke who are candidates for mechanical thrombectomy, thrombolytics (with alteplase or tenecteplase) will still be given in patients who meet inclusion criteria and have no exclusion criteria.
References
- Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association [published correction appears in Stroke. 2019 Dec;50(12):e440-e441]. Stroke. 2019;50(12):e344-e418. doi:10.1161/STR.0000000000000211
- Campbell BCV, Mitchell PJ, Churilov L, et al. Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke. N Engl J Med. 2018;378(17):1573-1582. doi:10.1056/NEJMoa1716405
- Kobeissi H, Ghozy S, Turfe B, et al. Tenecteplase vs. alteplase for treatment of acute ischemic stroke: A systematic review and meta-analysis of randomized trials. Front Neurol. 2023;14:1102463. Published 2023 Jan 23. doi:10.3389/fneur.2023.1102463
201集单集
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类似 HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast 的节目
Science Friction has a new series: Cooked. We dig into food science pickles. Why are studies showing that ice cream could be good for you? Do we really need as many electrolytes as the internet says? And why are people feeling good on the carnivore diet? Nutrition and food scientist Dr Emma Beckett takes us through what the evidence says about food categories and ingredients like meat, dairy and salt — and unpick why nutrition studies can be so conflicting and confusing. Airs Wednesday 11:30 ...
…
continue reading
PT Inquest is an online journal club. Hosted by Jason Tuori, Megan Graham, and Chris Juneau, the show looks at an article every week and discusses how it applies to current physical therapy practice.
…
continue reading
Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
…
continue reading
From the stuff your mother never told you, to the stuff your doctor never learned, On Health features taboo-busting conversations that demystify and de-stigmatize our bodies, all while bridging the gap between conventional medicine and wellness. Join Yale-trained MD & midwife Aviva Romm and her line-up of expert guests as they discuss everything from periods to menopause, sex to reproductive health politics, and motherhood to mental health. Each week, Dr. Romm will be exploring the science a ...
…
continue reading
Practical herbalism from practicing herbalists. Conversations, botanical deep-dives, Q&A with clinical herbalists Katja Swift & Ryn Midura of CommonWealth Holistic Herbalism.
…
continue reading
Seeking a healthier emotional life? It’s time to bring a trained psychologist and mental health expert along for the ride. Dr. Monica Johnson explains the why behind complex emotions, helps you form better relationships, and guides you down the path of self-understanding.
…
continue reading
From host Kevin Miller: When I was 7 years old and got out of line, my parents would give me an “attitude adjustment” and make me listen to motivational speakers like Zig Ziglar. I didn’t appreciate it at the time but the experience gave me awareness of how powerful our minds and outlook on life are. I went on to become a pro athlete, have 9 kids, start 17 businesses and become addicted to performance and production. Till I burnt out. Multiple times. That started a quest to not just pursue p ...
…
continue reading
As She Rises brings together local poets and activists from throughout North America to depict the effects of climate change on their home and their people. Each episode carries the listener to a new place through a collection of voices, local recordings and soundscapes. Stories span from the Louisiana Bayou, to the tundras of Alaska to the drying bed of the Colorado River. Centering the voices of native women and women of color, As She Rises personalizes the elusive magnitude of climate cha ...
…
continue reading
Lyngso Fitness Academy presents: The Missing Piece, an audio offering about the mission, mindset and mechanics of completely transforming your life.Ever wondered what is holding your back from your best life? Your best self? You know that something is missing.Welcome to the Missing Piece. Hosted by Paul Lyngso, this podcast provides you everything you need to finally achieve the next level of satisfaction in your life. By transforming your life from the inside out, Paul offers actionable ste ...
…
continue reading
Help me fill in the blanks of the practice of ED Critical Care. In this podcast, we discuss all things related to the crashing, critically ill patient in the Emergency Department. Find the show notes at emcrit.org.
…
continue reading
Player FM -播客应用
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