121: Understanding the Potential Cardiovascular Benefits of Low-Sodium Oxybate

NeurologyLive® Mind Moments®

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In this episode, Phil Jochelson, therapeutic head for Clinical Development Neuroscience at Jazz Pharmaceuticals, sat down to discuss the phase 4 XYLO study, a randomized controlled study evaluating the effects of switching from high-sodium to low-sodium oxybate on blood pressure in patients with narcolepsy. Jochelson gave some insight regarding the conduct of the trial, including end points, objectives, and patient demographics, as well as some of the benefits to studying blood pressure and cardiovascular risks. In addition, he discussed enhancements to narcolepsy care through low-sodium oxybate, the importance of unique studies like XYLO, and the need to educate clinicians on sodium load and its risks.
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Episode Breakdown:

• 1:15 – Reasons behind the XYLO study and links between high sodium intake and cardiovascular risk
• 4:45 – Patient demographics; inclusion and exclusion criterias
• 6:40 – Neurology News Minute
• 9:25 – Overview of XYLO and determining what a successful study looks like
• 15:30 – Improved understanding of the benefits of low-sodium oxybate

The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here:

• EU Regulatory Review Adopts Negative Opinion of Lecanemab as Treatment for Alzheimer Disease

• GLP-1 Agonist Liraglutide Shows Protective Effects on Alzheimer Disease in Phase 2 Trial

• FDA Approves Carbidopa/Levodopa ER Capsules Formulation IPX203 for Parkinson Disease

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