Ep. 21: How Seed Oils Promote Cancer—with Matt Quinn and Dr. Brian Kerley

Tucker Goodrich: Debugging Life

Introduction

Cancer is the second-leading killer of Americans, and is increasing both around the world and increasingly affecting younger and younger people.

It’s obviously important to understand what environmental factors might affect our susceptibility to the various cancers.

Here we discuss what I think is a key paper showing a link between our environment, genetic mutation, and metabolic dysfunction in cancer cells.

“The Major Lipid Peroxidation Product, Trans- 4-Hydroxy-2-Nonenal, Preferentially Forms DNA Adducts at Codon 249 of Human P53 Gene, a Unique Mutational Hotspot in Hepatocellular Carcinoma” (Hu et al., 2002)

Guest info

Matt Quinn

https://twitter.com/Mqsley

https://www.mquinn.online/

Biography:

TL;DR Here's what I am working on:

I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here​

I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this

I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here

In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here

I have failed at so so so many things - read about them here

https://www.mquinn.online/

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Co-host

Dr. Brian Kerley

https://www.seedoilrebellion.com/

https://twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?

Check out the Seedy app!

https://www.seedyapp.com/

Tucker Goodrich

Substack: https://tuckergoodrich.substack.com/

Twitter: https://twitter.com/TuckerGoodrich

Youtube: https://www.youtube.com/tuckergoodrich0

Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825

Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y

Podcast: https://sites.libsyn.com/408758

Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/

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Show Notes

Hu, W., Feng, Z., Eveleigh, J., Iyer, G., Pan, J., Amin, S., Chung, F.-L., & Tang, M. (2002). The Major Lipid Peroxidation Product, Trans- 4-Hydroxy-2-Nonenal, Preferentially Forms DNA Adducts at Codon 249 of Human P53 Gene, a Unique Mutational Hotspot in Hepatocellular Carcinoma. Carcinogenesis, 23(11), 1781–1789.

https://doi.org/10.1093/carcin/23.11.1781

Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection

https://amzn.to/3Unn39b

Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer

https://amzn.to/44pbz9C

Goodrich, T. D. (2021, July 8). Interview: Thomas Seyfried on Glioblastoma, Metabolic Cancer Breakthroughs, with David Gornoski on A Neighbor’s Choice [Blog]. Yelling Stop.

https://yelling-stop.blogspot.com/2021/07/podcast-interview-thomas-seyfried-with.html

Soussi, T. (2000). The P53 Tumor Suppressor Gene: From Molecular Biology to Clinical Investigation. Annals of the New York Academy of Sciences, 910, 121–137; discussion 137-139.

https://doi.org/10.1111/j.1749-6632.2000.tb06705.x

Matoba, S., Kang, J.-G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P. J., Bunz, F., & Hwang, P. M. (2006). P53 Regulates Mitochondrial Respiration. Science, 312(5780), 1650–1653.

https://doi.org/10.1126/science.1126863

The American Oil Chemists’ Society. (2004, June). Wilhelm Normann (1870-1939). INFORM Magazine.

https://lipidlibrary.aocs.org/resource-material/the-history-of-lipid-science-and-technology/wilhelm-normann-(1870-1939)

Goodrich, T. D. (2016, January 14). Thyroid and Low-Carb: What Do Thyroid Hormones Do? [Blog]. Yelling Stop.

https://open.substack.com/pub/tuckergoodrich/p/thyroid-and-low-carb-what-do-thyroid

If you have any questions about sources for things discussed please ask in the comments.