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407. Journal Club: The Nex-Z Trial – A CRISPR-Cas9 Based Treatment for ATTR Cardiac Amyloidosis with Dr. Ronald Witteles
Manage episode 461473381 series 2585945
内容由CardioNerds提供。所有播客内容（包括剧集、图形和播客描述）均由 CardioNerds 或其播客平台合作伙伴直接上传和提供。如果您认为有人在未经您许可的情况下使用您的受版权保护的作品，您可以按照此处概述的流程进行操作https://zh.player.fm/legal。
Join CardioNerds Heart Failure Section Chair Dr. Jenna Skowronski, episode lead Dr. Apoorva Gangavelli, and expert faculty Dr. Ronald Witteles as they discuss the Nex-Z trial.
This was a phase 1, open-label trial investigating nex-z, a CRISPR-Cas9-based treatment, in 36 patients with transthyretin amyloidosis with cardiomyopathy (ATTR-CM). The primary objectives were aimed at studying the safety and pharmacodynamics of this novel gene-based treatment modality. This episode dives into the nuances of the data, future directions for investigation, and future clinical implications.
US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here.
References – The Nex-Z Trial
Fontana, M., Solomon, S. D., Kachadourian, J., Walsh, L., Rocha, R., Lebwohl, D., Smith, D., Täubel, J., Gane, E. J., Pilebro, B., Adams, D., Razvi, Y., Olbertz, J., Haagensen, A., Zhu, P., Xu, Y., Leung, A., Sonderfan, A., Gutstein, D. E., & Gillmore, J. D. (2024). CRISPR-Cas9 Gene Editing with Nexiguran Ziclumeran for ATTR Cardiomyopathy. The New England Journal of Medicine. https://doi.org/10.1056/NEJMoa2412309
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Manage episode 461473381 series 2585945
内容由CardioNerds提供。所有播客内容（包括剧集、图形和播客描述）均由 CardioNerds 或其播客平台合作伙伴直接上传和提供。如果您认为有人在未经您许可的情况下使用您的受版权保护的作品，您可以按照此处概述的流程进行操作https://zh.player.fm/legal。
Join CardioNerds Heart Failure Section Chair Dr. Jenna Skowronski, episode lead Dr. Apoorva Gangavelli, and expert faculty Dr. Ronald Witteles as they discuss the Nex-Z trial.
This was a phase 1, open-label trial investigating nex-z, a CRISPR-Cas9-based treatment, in 36 patients with transthyretin amyloidosis with cardiomyopathy (ATTR-CM). The primary objectives were aimed at studying the safety and pharmacodynamics of this novel gene-based treatment modality. This episode dives into the nuances of the data, future directions for investigation, and future clinical implications.
US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here.
References – The Nex-Z Trial
Fontana, M., Solomon, S. D., Kachadourian, J., Walsh, L., Rocha, R., Lebwohl, D., Smith, D., Täubel, J., Gane, E. J., Pilebro, B., Adams, D., Razvi, Y., Olbertz, J., Haagensen, A., Zhu, P., Xu, Y., Leung, A., Sonderfan, A., Gutstein, D. E., & Gillmore, J. D. (2024). CRISPR-Cas9 Gene Editing with Nexiguran Ziclumeran for ATTR Cardiomyopathy. The New England Journal of Medicine. https://doi.org/10.1056/NEJMoa2412309
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类似 Cardionerds: A Cardiology Podcast 的节目
Practical herbalism from practicing herbalists. Conversations, botanical deep-dives, Q&A with clinical herbalists Katja Swift & Ryn Midura of CommonWealth Holistic Herbalism.
…
continue reading
For the complete newbie or the experienced hypnotist, Brain Software with Mike Mandel is the world's most interesting, educational and fun podcast discussing hypnosis, NLP and strategies for peak performance and self improvement. Mike Mandel is a 6-time award winning hypnotist, immensely popular keynote speaker, stage performer, psychotherapist and NLP trainer. He has been doing hypnosis since he was 12 years old. Mike has an amazing ability to demystify hypnosis, teach core concepts, and te ...
…
continue reading
Seeking a healthier emotional life? It’s time to bring a trained psychologist and mental health expert along for the ride. Dr. Monica Johnson explains the why behind complex emotions, helps you form better relationships, and guides you down the path of self-understanding.
…
continue reading
From the stuff your mother never told you, to the stuff your doctor never learned, On Health features taboo-busting conversations that demystify and de-stigmatize our bodies, all while bridging the gap between conventional medicine and wellness. Join Yale-trained MD & midwife Aviva Romm and her line-up of expert guests as they discuss everything from periods to menopause, sex to reproductive health politics, and motherhood to mental health. Each week, Dr. Romm will be exploring the science a ...
…
continue reading
Anxiety Slayer is an Award-Winning anxiety relief podcast with supportive tips, tools, and practices to help you calm anxiety, stress, PTSD, and panic attacks. Celebrating 700 episodes and over 13 million downloads! Visit AnxietySlayer.com to listen in and get our free Anxiety Slayer Starter Course.
…
continue reading
Making It is a weekly audio podcast that comes out every Friday hosted by Jimmy Diresta, Bob Clagett and David Picciuto. Three different makers with different backgrounds talking about creativity, design and making things with your bare hands.
…
continue reading
The Quote of The Day Show is your daily dose of inspiration, featuring the best-of-the-best speakers and prosperity teachers. Each episode spotlights an inspiring quote and 5-10 minute motivational audio clip to help you live a life you love. Featured speakers include Bob Proctor, Lisa Nichols, Tony Robbins, Les Brown, Jim Rohn, and more. Hosted by entrepreneur and money mindset expert Sean Croxton. Follow Sean on IG, Twitter, and FB at @seancroxton. Also, subscribe to his interview podcast, ...
…
continue reading
The Art of Charm is where self-motivated people, just like you, come to learn from the company’s coaches about to how to master human dynamics, relationships, and becoming your best self with the help of Johnny and AJ, the company’s founders. Johnny and AJ bring their 11 years of coaching experience from their famous Bootcamps, where they host clients in Los Angeles from all over the world and they share their stories, best practices and themselves on this weekly podcast. Not only does The A ...
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continue reading
We are often distracted in life and never really dive deep into the real foundation of self improvement, goal achieving, and wellbeing. - Join our team of experts every week as we discuss the real facets of manhood. Topics like: How to develop more self esteem, self love, deeper relationships. How to improve our wellbeing, mental toughness, resilience, and productivity. How to develop critical skills, become better leaders, expand our careers/business, create financial security and contribut ...
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使用Player FM应用程序离线！
