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Is the Deadliest Condition Preventable? Understanding ASCVD and LDL-C

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Manage episode 462095589 series 3555208
内容由MedEvidence Articles提供。所有播客内容(包括剧集、图形和播客描述)均由 MedEvidence Articles 或其播客平台合作伙伴直接上传和提供。如果您认为有人在未经您许可的情况下使用您的受版权保护的作品,您可以按照此处概述的流程进行操作https://zh.player.fm/legal

This episode explores atherosclerotic cardiovascular disease (ASCVD), the leading cause of heart attacks and strokes worldwide. Learn about the role of LDL cholesterol in the development of fatty plaques that harden and block blood vessels, as well as the risks associated with ASCVD, including heart disease and peripheral artery disease. The episode highlights preventive strategies such as healthy lifestyle changes and treatments like statins, PCSK9 inhibitors, and emerging clinical trial therapies. Discover how understanding and managing LDL cholesterol levels can help reduce the burden of this preventable yet most deadly condition.
Share with a friend. Rate, Review, and Subscribe to MedEvidence Articles to be notified when new episodes are released.

Follow us on Social Media:
Facebook
Instagram
Twitter
LinkedIn
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For more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! podcast. www.MedEvidence.com

Thank you for listening!

References:

Makover, M. E., Shapiro, M. D., & Toth, P. P. (2022). There is urgent need to treat atherosclerotic cardiovascular disease risk earlier, more intensively, and with greater precision: A review of current practice and recommendations for improved effectiveness. American Journal of Preventive Cardiology, 12, 100371. https://pmc.ncbi.nlm.nih.gov/articles/PMC9482082/

World Health Organization. (7 August, 2024). The top 10 causes of death. [website]. Accessed 16 December, 2024. https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death

Ference, B. A., et al. (2017). Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. European heart journal, 38(32), 2459-2472. https://academic.oup.com/eurheartj/article/38/32/2459/3745109

Ferhatbegović, L., Mršić, D., Kušljugić, S., & Pojskić, B. (2022). LDL-C: the only causal risk factor for ASCVD. Why is it still overlooked and underestimated?. Current Atherosclerosis Reports, 24(8), 635-642. https://link.springer.com/article/10.1007/s11883-022-01037-3

Mundi, S., et al. (2018). Endothelial permeability, LDL deposition, and cardiovascular risk factors—A review. Cardiovascular research, 114(1), 35-52. https://pmc.ncbi.nlm.nih.gov/articles/PMC7729208/

Jebari-Benslaiman, S., et al. (2022). Pathophysiology of atherosclerosis. International journal of molecular sciences, 23(6), 3346. https://www.mdpi.com/1422-0067/23/6/3346

Arnett, D. K., et al. (2019). 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Journal of the American College of cardiology, 74(10), e177-e232. https://www.ahajournals.org/doi/10.1161/CIR.0000000000000678

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Manage episode 462095589 series 3555208
内容由MedEvidence Articles提供。所有播客内容(包括剧集、图形和播客描述)均由 MedEvidence Articles 或其播客平台合作伙伴直接上传和提供。如果您认为有人在未经您许可的情况下使用您的受版权保护的作品,您可以按照此处概述的流程进行操作https://zh.player.fm/legal

This episode explores atherosclerotic cardiovascular disease (ASCVD), the leading cause of heart attacks and strokes worldwide. Learn about the role of LDL cholesterol in the development of fatty plaques that harden and block blood vessels, as well as the risks associated with ASCVD, including heart disease and peripheral artery disease. The episode highlights preventive strategies such as healthy lifestyle changes and treatments like statins, PCSK9 inhibitors, and emerging clinical trial therapies. Discover how understanding and managing LDL cholesterol levels can help reduce the burden of this preventable yet most deadly condition.
Share with a friend. Rate, Review, and Subscribe to MedEvidence Articles to be notified when new episodes are released.

Follow us on Social Media:
Facebook
Instagram
Twitter
LinkedIn
Tiktok
Youtube

For more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! podcast. www.MedEvidence.com

Thank you for listening!

References:

Makover, M. E., Shapiro, M. D., & Toth, P. P. (2022). There is urgent need to treat atherosclerotic cardiovascular disease risk earlier, more intensively, and with greater precision: A review of current practice and recommendations for improved effectiveness. American Journal of Preventive Cardiology, 12, 100371. https://pmc.ncbi.nlm.nih.gov/articles/PMC9482082/

World Health Organization. (7 August, 2024). The top 10 causes of death. [website]. Accessed 16 December, 2024. https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death

Ference, B. A., et al. (2017). Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. European heart journal, 38(32), 2459-2472. https://academic.oup.com/eurheartj/article/38/32/2459/3745109

Ferhatbegović, L., Mršić, D., Kušljugić, S., & Pojskić, B. (2022). LDL-C: the only causal risk factor for ASCVD. Why is it still overlooked and underestimated?. Current Atherosclerosis Reports, 24(8), 635-642. https://link.springer.com/article/10.1007/s11883-022-01037-3

Mundi, S., et al. (2018). Endothelial permeability, LDL deposition, and cardiovascular risk factors—A review. Cardiovascular research, 114(1), 35-52. https://pmc.ncbi.nlm.nih.gov/articles/PMC7729208/

Jebari-Benslaiman, S., et al. (2022). Pathophysiology of atherosclerosis. International journal of molecular sciences, 23(6), 3346. https://www.mdpi.com/1422-0067/23/6/3346

Arnett, D. K., et al. (2019). 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Journal of the American College of cardiology, 74(10), e177-e232. https://www.ahajournals.org/doi/10.1161/CIR.0000000000000678

  continue reading

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