最佳John Huff播客 (2024)

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Episode #202: Caught In Time With Adam Stanley 1:22:59

5d ago1:22:59

1:22:59

On Episode #202, your humble host sits down with Adam Stanley – drummer for the popular rock band Breed 77 and host of the Caught In Time Podcast. Adam grew up in South Africa before moving to England to chase his musical dreams. Join us for a poignant chat about taking chances, seizing opportunities, rising to challenges, and launching a podcast t…

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EP 150: Cracking the biological code of aging with Martin Borch Jensen, Co-Founder and Chief Scientific Officer at Gordian Biotechnology 44:21

3d ago44:21

44:21

0:00 Intro to The Genetics Podcast 01:00 Welcome to Martin 01:35 How a particularly large Indian meal resulted in a book about intermittent fasting and the biology of ageing 05:10 The biological mechanisms behind intermittent fasting, and whether it’s been established to extend life expectancy in humans. 10:13 What we know (and what we don’t) about…

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EP 149: Sequencing 33 million samples to support the UK’s COVID-19 response with Tony Cox, CEO of UK Biocentre 34:16

5h ago34:16

34:16

0:00 Intro to The Genetics Podcast 01:00 Welcome to Tony 02:00 What Tony was expecting going into the role of CEO at UK Biocentre, and how the COVID-19 pandemic changed his plans 03:38 Receiving a phone call from the UK government in March 2020 asking the UK Biocentre to stop all of its projects and focus on sequencing COVID-19 samples 05:12 The UK…

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EP 148: Advancing veteran health through the Million Veteran Program with Dr. Mike Gaziano, professor of medicine at Harvard Medical School 35:13

23h ago35:13

35:13

0:00 Intro 2:00 Mike’s career prior to the Million Veteran Program (MVP), how Mike got to work on MVP, and important milestones in the project's evolution 8:30 Future goals for the Million Veteran Program in expanding and diversifying the research cohort 11:00 The roles of various omics in advancing the project's development 14:30 The most meaningf…

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Episode #201: Doing Things Your Way With Skye Wallace 1:12:08

19d ago1:12:08

1:12:08

On Episode #201, your humble host sits down with Toronto-based artist Skye Wallace to talk about music, managing mental health, writing and recording with Hawksley Workman, playing in Europe, the Weakerthans, and how the best thing you can ever be is yourself. Follow Skye at www.skyewallace.com. Follow the show at www.john-huff.com. * Door close so…

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EP 147: From research to delivering precision medicine in the clinic with Scott Weiss, Professor of Medicine at Harvard University 37:19

24d ago37:19

37:19

0:00 Intro to The Genetics Podcast 01:00 Welcome to Scott 01:55 Scott’s career highlights to date, ranging from epidemiology to the genetics of asthma and chronic obstructive pulmonary disease (COPD) 04:56 How and why Scott decided to transition into genetics 06:30 The advances in our understanding of the genetics of asthma and COPD over the past 2…

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EP 146: The biology of aging with Austin Argentieri, Research Fellow at Harvard Medical School, Affiliate Member of the Broad Institute, and Research Fellow at Massachusetts General Hospital 43:05

1M ago43:05

43:05

0:00 Intro to The Genetics Podcast 01:00 Welcome to Austin 01:42 What is aging and how should we think about it? 03:50 Discussion of Austin’s recent breakthrough paper on aging, including the questions he set out to answer, and the outcomes of the research 06:32 How Austin’s work focuses on using large-scale population proteomics data to create acc…

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EP 145: Navigating rare disease drug development regulations with Daniel O’Connor 39:12

1M ago39:12

39:12

0:00 Intro to The Genetics Podcast 01:00 Welcome to Daniel 02:04 Defining rare disease in the age of personalized medicine 04:57 Key touchpoints with the Medicines and Healthcare products Regulatory Agency (MHRA) when developing a new medicine 09:27 Improvements over the course of Daniel’s career when it comes to incentivizing and making the path t…

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EP 144: Research Roundup with Dr. Veera: breakthroughs in developmental disorders, Parkinson's, SLE, and Alzheimer's 56:48

1M ago56:48

56:48

0:00 Introduction 1:40 A recurrent de novo mutation in a noncoding region of a small nucleolar RNA gene that has been identified as one of the most common causes of neurodevelopmental disorders This pathogenic variant escaped notice for years because it was not located in a protein coding region of the genome It now shows potential as a target for …

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Episode #200: Forward Momentum 54:00

2M ago54:00

54:00

On Episode #200, your humble host reflects on playing a Pride celebration, and waxes semi-eloquent about how the gig symbolizes both musical and personal growth, the Indigo Girls documentary It’s Only Life After All, new music by Rosalie James, krautrock, and the motorik beat. Follow the show at www.john-huff.com. Support on Patreon at www.patreon.…

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EP 143: Harnessing human data in drug development with Jakob Steinfeldt, Co-Founder and Chief Scientific Officer at Pheiron 36:17

2M ago36:17

36:17

0:00 Intro to The Genetics Podcast 01:00 Welcome to Jakob and background on Pheiron 02:14 What made Jakob decide to start Pheiron, what the company does, and how his scientific background inspired him to found a start-up 5:24 Jakob’s excitement and inspiration around the power and potential of machine learning 07:07 Cardiology and heart failure as …

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Episode #199: Not Dying Is Good 45:48

2M ago45:48

45:48

On Episode #199, your humble host considers the good over the bad, and waxes semi-eloquent about not dying in a very dangerous traffic incident, playing great gigs with great people, conquering Whipping Post, and exciting news from Galactic Cowboys. Oh, and above all else, holding on to hope. Follow the show at www.john-huff.com. Support on Patreon…

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Finding Common Ground in a Divided Congress: Reps. Brian Fitzpatrick (R) and Abigail Spanberger (D) 28:33

2M ago28:33

28:33

This episode makes a powerful case for compromise and pragmatism as crucial ingredients in passing laws and getting things done. Our guests are Democrat Abigail Spanberger and Republican Brian Fitzpatrick, who are both members of the Problem Solvers Caucus: 62 Members of Congress, evenly split between Republicans and Democrats. Although you wouldn’…

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EP 142: From genome to bedside: How genetics is transforming modern medical practice with Dr. Andrea Gropman 42:45

2M ago42:45

42:45

0:00 Introduction 1:40 Andrea’s background and how she got into the field of genetics, neuroimaging, and metabolic disorders 4:00 Insights into Andrea’s clinical practice, including the diverse families and patients she serves and her approach to clinical decision-making 6:30 How genetics and genomics have changed the diagnostic journey in the last…

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Episode #198: In Praise Of ... Nickelback?! 53:17

2M ago53:17

53:17

On Episode #198, your humble host digs into three music documentaries – Hate To Love: Nickelback, Let There Be Drums, and Ghost’s Rite Here Rite Now – and waxes semi-eloquent about recognizing the good old days, paying your dues, acclimatizing to fame, and rekindling inspiration. Follow the show at www.john-huff.com. Support on Patreon at www.patre…

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EP 141: Bringing genomics to the clinic with Lori Orlando, Associate Prof at Duke University 43:24

2M ago43:24

43:24

0:00 Intro to The Genetics Podcast 01:00 Welcome to Lori Orlando 03:00 Lori’s career: From mathematical modelling to genetics and family history 05:11 The study that revealed 20% of the general population is at a higher risk of disease than average and needs preventative care 07:36 The first five diseases that Lori started analysing through informa…

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EP 140: The future of Electronic Health Records and data analysis with Ben Goldacre 52:51

2M ago52:51

52:51

0:00 Intro to The Genetics Podcast 1:00 Welcome to Ben Goldacre 02:22 Ben’s open data projects at the Bennett Institute and the challenges they aim to tackle 04:03 Using Electronic Health Records (EHR) to help the National Health Service improve care 06:18 The importance of software development within healthcare data and how to manage salary scales…

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Public Schools: Talking Across the Divide. Becky Pringle and Gisele Huff 23:26

3M ago23:26

23:26

Almost everyone has an opinion about public education, especially in the years since the COVID pandemic when the physical closure of schools and online schooling became highly controversial. The vast majority of American students attend public school, but the numbers are falling, partially because of growing financial support for school choice and …

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EP 139: Rare disease breakthroughs using tRNA with Michelle Werner, CEO of Alltrna and CEO-Partner of Flagship Pioneering 44:42

3M ago44:42

44:42

0:00 Intro to The Genetics Podcast. 01:00 Welcome to Michelle. 02:00 Sstop codon diseases and how are they characterised 03:45 Diseases caused by premature stop codons in haploinsufficient genes. 04:35 The role of transfer RNA technology in finding solutions for premature stop codon diseases. 06:16 How Alltrna is engineering tRNAs which can bind to…

1
Episode #197: I Need A Break 53:21

3M ago53:21

53:21

On Episode #197, your humble host announces – after a solid two-year stretch that includes 100 published episodes – a brief vacation from the podcast, and waxes semi-eloquent about creative blocks, the importance of taking breaks, getting quiet, listening to and trusting your intuition, and new music by Rowena Wise. Follow the show at www.john-huff…

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Pro-Life and Pro-Choice Leaders Together in the Same Room: Reverend Anne Fowler and Francis Hogan 27:53

3M ago27:53

27:53

Abortion is one of the most passionate, divisive, and emotional issues in the 2024 election campaign. The debate is often dominated by extremes on both sides. But what if passionate pro-life and pro-choice movement leaders could get together in the same room and learn how to disagree better? That is exactly what happened in Massachusetts, beginning…

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EP 138: Personalised medicine using microbiome models with Dr. Almut Heinken 40:22

3M ago40:22

40:22

0:00 Introduction 1:45 Almut’s research experience, including two recent publications on genome-scale metabolic reconstruction human microorganisms Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine APOLLO: A genome-scale metabolic reconstruction resource of 247,092 diverse human microbes spanning multiple…

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Episode #196: The Game You Choose To Play With Kay Howl 1:05:53

3M ago1:05:53

1:05:53

On Episode #196, your humble host welcomes – from somewhere off the coast of Greece – podcast favourite Kay Howl for an impromptu chat about the highs and lows of performing on cruise ships, library felons, social media influencers, shoilets, resilience, faith, and choosing what to focus on in a world of superficial distractions. Follow Kay on Inst…

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EP 137: Mavis Machirori on promoting equity, diversity, and social justice in genomics research 41:40

3M ago41:40

41:40

0:00 Intro 1:30 Mavis’ career arc, from starting as a midwife to researching medical innovation and technology with an emphasis on advocacy and equity 7:00 Systemic issues that are easily overlooked in medical research and advancements Webinar: Participant Diversity: Increasing the Impact of Biomedical Research Webinar 10:00 Addressing Eurocentrici…

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Episode #195: Struggle Guilt 44:57

3M ago44:57

44:57

Why do we cling to the myth that creating art should be a struggle? Why do we feel guilty for wanting more in life? How much of what we desire is ego and how much is our higher self leading us on the path to our greatest potential and contribution? On Episode #195, your humble host tackles these important questions, and waxes semi-eloquent about hi…

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EP 136: Developments in ring chromosome 20 research and advocacy with Allison Watson 40:57

4M ago40:57

40:57

0:00 Introduction 2:00 Allison’s personal journey to researching epilepsy and ring chromosome 20 syndrome 4:00 Biggest challenges families face with ring chromosome 20 syndrome 11:00 Incidence and prevalence of r(20) syndrome, and how we can improve data reliability 21:00 Applying next generation sequencing to r(20) syndrome gene research 29:00 Eng…

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How The Media Rage Machine Divides America: Chris Stirewalt 28:23

4M ago28:23

28:23

From cars to entertainment, technology to retailing, most large industries have faced huge changes in the past thirty years. But none more so than the news business. Since 2000, countless numbers of local and regional newspapers went bust. Those that did survive fired a big percentage of their reporters and slimmed down. The past two decades also s…

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Episode #194: Following Your Heart (The Tao Of God's Naked Butt) 58:29

4M ago58:29

58:29

This week, your humble host reflects on a Ram Dass quote about expressing divinity through art, and waxes semi-eloquent about visiting Vatican City, Michelangelo’s genius, trusting your artistic instincts, and being a podcasting Mother Teresa. All that, plus very relevant new music by Nada Surf, on Episode #194! Follow the show at www.john-huff.com…

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EP 135: Integration of newborn sequencing programs into healthcare systems with Dr. Ingrid Holm 41:16

4M ago41:16

41:16

0:00 Introduction 1:30 Ingrid’s initial interests in genetics, paediatrics, and newborn screening 2:45 How the original BabySeq project, a pioneering newborn sequencing program got started, how it’s going, and the launch of BabySeq2 8:45 Lessons from BabySeq1 and goals for BabySeq2 10:30 Potential societal and long-term considerations for those inv…

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Episode #193: The Latte And The Tea Party 50:07

4M ago50:07

50:07

This week, your humble host shares a disappointing coffee story, and waxes semi-eloquent about performing at the 24-hour Drum Marathon with Jeff Burrows of The Tea Party, learning from pro players, and finding your tribe. All that, plus new music by spiderblush, on Episode #193! Follow the show at www.john-huff.com. Support on Patreon at www.patreo…

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EP 134: Prenatal genetic testing and the future of AI in genetic counselling with Kira Dineen, host of DNA Today 40:44

4M ago40:44

40:44

0:00 Introduction 1:00 The backstory of how Kira first started DNA Today in 2012, when she was still in high school! 3:30 Some of Kira’s favourite topics she has discussed on DNA Today, including the legacy of Henrietta Lacks, and the story of a Glee actress with down syndrome 10:00 Kira’s best practices for podcasting, from over 10 years of experi…

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Why Trump is Popular in Small-Town America: Salena Zito 26:48

4M ago26:48

26:48

Unlike the vast majority of journalists who cover American politics, Salena Zito lives far away from the centers of power and wealth. She writes about small-town America and the parts of the country that much of the media doesn’t cover. Zito's commitment to understanding the heartland of America is evident in her frequent trips along the nation’s b…

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Mr. John Crawford & the Importance of Family 21:02

4M ago21:02

21:02

Welcome to the seventh episode of bOLDer People! In this episode, guest host, and former bOLDer People Producer, Leah Flake invites John Crawford into the studio. John is a retired engineer who now spends his time working in record preservation. He and his wife, Sherry, volunteer to digitize historical records, to make them available to the public …

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Episode #192: Can The Leafs Lose To Someone Else, Please? 56:44

4M ago56:44

56:44

On Episode #192, your humble host waxes semi-eloquent about Toronto vs. Boston as a Canadiens fan, sports fandom and personal growth, Anglo-French history, a sight of intense revulsion in Amsterdam, lessons from trees, and new music by Petey and Unto Others. Follow the show at www.john-huff.com. Support on Patreon at www.patreon.com/johnhuffpodcast…

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Bass Edge's The Edge-Episode 422 In Depth - Tournament Talk 59:15

4M ago59:15

59:15

Did you know these things that went on in recent National Tournaments?!?Bass Edge host, Kurt Dove and bass fishing nut Rich 'Hellabass' Lindgren, discussed some interesting tid-bits about national tournament bass fishing events over the past few weeks. Kurt and Rich reveal some behind-the-scenes happenings as well as recent techniques you should be…

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EP 133: Insights into pharmacogenomics and increasing diversity in genomics research with Dr. Emma Magavern 39:17

4M ago39:17

39:17

0:00 Introduction 2:00 The value of an English Literature degree in designing and analysing research studies in medicine 3:45 Emma’s entrance to pharmacogenomics and her transition from practising physician to genetics research 6:00 How the East London Genes and Health program is increasing representation of diverse populations, namely South Asians…

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Bass Edge's The Edge-Episode 421 ISH MONROE 36:46

4M ago36:46

36:46

Ish Monroe, Still Power Fishing his way into Top 10's!Bass Edge host, Kurt Dove, sits down with BASS Elite pro angler, Ish Monroe, to highlight a busy 2024 spring tournament schedule and talk about his successes. Ish continues to fish his strengths and be successful and a few new and old lures that he is relying on to catch bigger bass than most in…

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Episode #191: Heya Kelowna! 55:19

4M ago55:19

55:19

On Episode #191, your humble host digs deeper into the infamous Kelowna gig with Carly Thomas, and waxes semi-eloquent about train life, picking up your artist as a side player, managing rough gigs, mountain runaway lanes, living in the present, and new music by Sebastian Bach. Follow the show at www.john-huff.com. Support on Patreon at www.patreon…

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EP 132: From mammoths to genome editing, trailblazing genetics with Dr. George Church 47:41

5M ago47:41

47:41

0:00 Introduction 1:00 George’s upcoming big projects, including developing full recycling, renewing energy, creating bioweather maps, and harnessing citizen science 6:45 Progress in engineering viral resistance in humans, including thoughts from pre- and post- pandemic 11:00 A swapped genetic code that prevents viral infections and gene transfer b…

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Bipartisan Trust and Common Ground in Congress: Reps. Dusty Johnson (R) and Raja Krishnamoorthi (D) 29:31

5M ago29:31

29:31

More than 50 Members of Congress have announced that they’re not running for reelection in 2024. Many cite political dysfunction and angry divisive rhetoric as reasons behind their decision to quit. Retiring Democratic Senator Joe Manchin recently told CNN: “Every one of us should be ashamed of what we’re living through now in the 118th Congress.” …

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Episode #190: Gretchen Goes To Toronto 54:52

5M ago54:52

54:52

Why is your humble host’s voice ravaged on this week’s episode? What does it have to do with attending the First Church Of Rock And Roll – aka a King’s X show – in Toronto? What’s the true value of participating in a battle of the bands? And how does it feel to have a five-lane highway all to yourself? All of that, plus new music by Avalon Stone an…

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EP 131: The potential of somatic genomics in drug discovery and development with Jake Rubens 44:57

5M ago44:57

44:57

0:00 Intro 0:40 Jake’s experiences as a serial entrepreneur starting five companies with a basis in genomic science 5:30 Opportunities for research and drug development in the realm of somatic science 9:20 Somatic evolution and how it provides valuable insights into disease mechanisms 12:30 Advantages and disadvantages of studying germline genome-w…

1
Episode #189: Hey Pinko! 55:25

5M ago55:25

55:25

What would your humble host do if he won a lot of money? Which footballer inspires his answer to that question? What’s wrong with Hollywood? And what was the Battle Of The Eclipse anyway? All of that – plus another controversial food take and new music by Invasion – on Episode #189! Follow the show at www.john-huff.com. Support on Patreon at www.pa…

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EP 130: Quarterly insights into noncoding variants and GWAS with Dr. Veera Rajagopal 51:56

5M ago51:56

51:56

Show Notes: 0:00 Introduction 1:20 How polydactyl mutations can inform research on non-coding variant mechanisms The importance of low-affinity binding between transcription factors and targets How these lessons can help us improve our understanding of drug and target discovery See Veera’s January round-up for more information: https://www.gwasstor…

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Curiosity, Not Compliance: Bridge Building In The Workplace: Simon Greer 30:32

5M ago30:32

30:32

Many Americans are exhausted by polarization and hyper-partisanship. Bitter divides are not just a problem for election campaigns and public institutions; they’re also damaging the workplace. Employee morale at many businesses and nonprofits has plunged— impacted by tribalism, culture wars, and political divides. CEOs are often in a tough spot. Som…

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Episode #188: Fifth Anniversary Q&A (The Tao of Pineapple On Pizza) 56:47

5M ago56:47

56:47

On the fifth anniversay episode of the podcast, your humble host answers listener questions, and waxes semi-eloquent about the hard parts of running a podcast, having no hands, the pros and cons of starting a band, being Ringo, and yes, pineapple on pizza. All that, plus new music by Issa, on Episode #188! Follow the show at www.john-huff.com. Supp…

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EP 129: Patient advocacy for genetic ALS and FTD with Jean Swidler, Executive Director of End the Legacy 38:44

5M ago38:44

38:44

0:00 Introduction 0:45 Jean’s personal experiences with family members with genetic ALS 10:00 Jean’s thoughts on the barriers and facilitators to providing treatment for those with genetic ALS 13:20 Insights into C9orf72, a common genetic determinant of ALS, and how it can also be associated with FTD 16:10 Jean’s experiences as an active advocate f…

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Episode #187: It All Comes Out At The Four-Way Stop 56:42

5M ago56:42

56:42

What did your humble host recently learn about himself at a four-way stop? How does the information you consume affect your mood? And what’s it like sleeping with an elephant? All that, plus new music by Hitsujibungaku and Everlet, on Episode #187! Follow the show at www.john-huff.com. Support on Patreon at www.patreon.com/johnhuffpodcast. * Door c…

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Bass Edge's The Edge-Episode 420 CODY HUFF 52:41

5M ago52:41

52:41

Cody Huff makes the most impressive daily adjustment to finish 3rd at the 2024 Bassmaster Classic!Bass Edge visits with the 3rd place finisher at the 2024 Bassmaster Classic Cody Huff in the most recent Feature Angler Spotlight on Bass Edge Radio!MLF/Bass Pro Tour angler James Watson is suspended from all MLF organization competition through Decemb…

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EP 128: Parkinson’s disease and precision medicine with Drs. James Beck and Ignacio Mata 50:18

5M ago50:18

50:18

0:00 Introduction 1:05 Insights into the PD GENEration’s (a programme from the Parkinson's Foundation) milestones and progress points for the upcoming year 3:30 The shifting attitudes and perspectives of neurologists and healthcare workers at the PD GENEration 5:50 Insights into Nacho’s work with the genetics of Parkinson’s disease 10:20 Barriers a…

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John Huff播客

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