EP 141: Bringing genomics to the clinic with Lori Orlando, Associate Prof at Duke University

The Genetics Podcast

0:00 Intro to The Genetics Podcast

01:00 Welcome to Lori Orlando

03:00 Lori’s career: From mathematical modelling to genetics and family history

05:11 The study that revealed 20% of the general population is at a higher risk of disease than average and needs preventative care

07:36 The first five diseases that Lori started analysing through informatics

09:56 The emergence of implementation science

11:47 Helping patients understand the implications and limitations of different types of genetic testing

13:11 The biggest challenges for the evolution of genomics and genetic testing

15:28 Emerging tools physicians can share to help patients understand genetic testing and its impacts

18:06 How primary care doctors can use genetic testing results to identify clear treatment pathways for specific conditions

24:33 The evolution of genetic counselling in primary care in the context of monogenic disease

28:34 Conditions where genetics, behaviour, and environment are deeply linked and where behaviour change can act as a preventative measure

35:00 Providing overall assessments to patients, including genetic testing and family history, to see how it changes their healthcare

35:50 How the MeTree platform is helping patients understand family health history

37:41 How to optimise family health history for current healthcare

42:15 Closing remarks

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