Beyond LDL-Cholesterol: These Culprits Drive Artery Plaque Build Up

High Intensity Health with Mike Mutzel, MS

内容由Mike Mutzel, Author Mike Mutzel interviews Jeff Bland, Datis Kharrazian, Ben Greenfield, Abel James, Dave Asprey, Ben Lynch, Jade Teta, and Corey chuler提供。所有播客内容（包括剧集、图形和播客描述）均由 Mike Mutzel, Author Mike Mutzel interviews Jeff Bland, Datis Kharrazian, Ben Greenfield, Abel James, Dave Asprey, Ben Lynch, Jade Teta, and Corey chuler 或其播客平台合作伙伴直接上传和提供。如果您认为有人在未经您许可的情况下使用您的受版权保护的作品，您可以按照此处概述的流程进行操作https://zh.player.fm/legal。

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For the past 60 years the medical community has obsessively focused on lowering LDL-cholesterol levels…

Research shows these five preventable health conditions make LDL-Cholesterol more likely to cause artery plaque build-up, even if your LDL-Cholesterol levels are low.

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Link to Video and Show Notes: https://bit.ly/3WfpI5R

Research Mentioned:

Zanoni, P., Velagapudi, S., Yalcinkaya, M., Rohrer, L. & Eckardstein, A. von. Endocytosis of lipoproteins. Atherosclerosis 275, 273–295 (2018).

Ference, B. A., Braunwald, E. & Catapano, A. L. The LDL cumulative exposure hypothesis: evidence and practical applications. Nat. Rev. Cardiol. 1–16 (2024) doi:10.1038/s41569-024-01039-5.

Time Stamps:

00:45 LDL's link with atherosclerosis is nuanced.

02:30 Initial damage to the arterial wall makes LDL levels problematic.

03:45 Increases risk of arterial wall damage: elevated blood pressure, insulin resistance/diabetes, smoking/vaping, obesity, elevated blood viscosity, consuming oxidizableoils.

08:40 High LDL and high triglycerides suggest insulin resistance and increased cardiovascular risk.

09:50 Start with diet and exercise together.

11:20 Statins have concerning side effects.

13:15 Plaque formation begins early in life.

13:50 High LDL is found in centenarians.

14:44 Centenarians are metabolically healthy.

15:40 Your liver makes LDL cholesterol.

16:10 Every cell in your body requires cholesterol.

18:00 Diets high in seed oils make your LDL more likely to be oxidized.

20:55 30-50% of people who have heart attacks have optimal serum cholesterol.

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